Synthesis and evaluation of antioxidant and antibacterial activities of new substituted bis(1,3,4-oxadiazoles), 3,5-bis(substituted) pyrazoles and isoxazoles

Ebraheem Abdu Musad, Riyaz Mohamed, Bahjat Ali Saeed, Bannikuppe S Vishwanath, K M Lokanatha Rai

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

Two series of five membered heterocyclic bis(1,3,4-oxadiazole) derivatives 2(a-h) and 3,5-bis(substituted)pyrazoles, isoxazoles 3(a,b,d-i), 4(a-c) were synthesized via oxidative cyclization of some diaroylhydrazones using chloramine-T and cyclocondensation reaction with hydrazine hydrate and hydroxylamine hydrochloride, respectively. The newly synthesized compounds were screened for antioxidant and anti-microbial activities. Compounds 2(b), 3(b), and 4(a) showed higher antioxidant activity at 10 μg/ml while compounds 2(a), 3(a), 3(f), and 4(a) exhibited better anti-microbial activity at 100μg/ml compared with standard vitamin C and ciprofloxacin, respectively. Structures of newly synthesized compounds were confirmed by elemental analysis and spectral IR, (1)H NMR, and (13)C NMR data.

Original languageEnglish (US)
Pages (from-to)3536-40
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number12
DOIs
StatePublished - Jun 15 2011

Keywords

  • Anti-Bacterial Agents/chemical synthesis
  • Antioxidants/chemical synthesis
  • Bacteria/drug effects
  • Isoxazoles/chemical synthesis
  • Lipid Peroxidation/drug effects
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Oxadiazoles/chemical synthesis
  • Pyrazoles/chemical synthesis

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