Abstract
Two series of five membered heterocyclic bis(1,3,4-oxadiazole) derivatives 2(a-h) and 3,5-bis(substituted)pyrazoles, isoxazoles 3(a,b,d-i), 4(a-c) were synthesized via oxidative cyclization of some diaroylhydrazones using chloramine-T and cyclocondensation reaction with hydrazine hydrate and hydroxylamine hydrochloride, respectively. The newly synthesized compounds were screened for antioxidant and anti-microbial activities. Compounds 2(b), 3(b), and 4(a) showed higher antioxidant activity at 10 μg/ml while compounds 2(a), 3(a), 3(f), and 4(a) exhibited better anti-microbial activity at 100μg/ml compared with standard vitamin C and ciprofloxacin, respectively. Structures of newly synthesized compounds were confirmed by elemental analysis and spectral IR, (1)H NMR, and (13)C NMR data.
Original language | English (US) |
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Pages (from-to) | 3536-40 |
Number of pages | 5 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 21 |
Issue number | 12 |
DOIs | |
State | Published - Jun 15 2011 |
Keywords
- Anti-Bacterial Agents/chemical synthesis
- Antioxidants/chemical synthesis
- Bacteria/drug effects
- Isoxazoles/chemical synthesis
- Lipid Peroxidation/drug effects
- Magnetic Resonance Spectroscopy
- Molecular Structure
- Oxadiazoles/chemical synthesis
- Pyrazoles/chemical synthesis