Synthesis and QSAR studies of some novel disubstituted 1,2,4-triazoles as antimicrobial agents

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6 Scopus citations

Abstract

Disubstituted 1,2,4-triazoles 3a-k, 4a-k, and 6a-k have been synthesized from anthranilic acid and nicotinic acid, respectively, through a multi-step reaction sequence via their hydrazides. Synthesized compounds were evaluated for their in vitro antimicrobial activity against two gram-positive bacteria (S. aureus and B. subtilis), three gram-negative bacteria (E. coli, S. typhi, and K. pneumonia) as well as four fungi (A. niger, A. fumigatus, A. flavus, and C. albicans). To explore computational approach, structure-activity relationships were generated statistically using the synthesized compounds and their respective quantitative values of biological activities. These models can be used in future for predicting antimicrobial activity on similar class of compounds.

Original languageEnglish (US)
Pages (from-to)848-861
Number of pages14
JournalMedicinal Chemistry Research
Volume23
Issue number2
DOIs
StatePublished - Feb 2014

Keywords

  • 1,2,4-Triazoles
  • Antibacterial
  • Antifungal
  • Pyridine
  • QSAR
  • Quinazoline

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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