Synthesis and QSAR studies of some novel disubstituted 1,2,4-triazoles as antimicrobial agents

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Disubstituted 1,2,4-triazoles 3a-k, 4a-k, and 6a-k have been synthesized from anthranilic acid and nicotinic acid, respectively, through a multi-step reaction sequence via their hydrazides. Synthesized compounds were evaluated for their in vitro antimicrobial activity against two gram-positive bacteria (S. aureus and B. subtilis), three gram-negative bacteria (E. coli, S. typhi, and K. pneumonia) as well as four fungi (A. niger, A. fumigatus, A. flavus, and C. albicans). To explore computational approach, structure-activity relationships were generated statistically using the synthesized compounds and their respective quantitative values of biological activities. These models can be used in future for predicting antimicrobial activity on similar class of compounds.

Original languageEnglish (US)
Pages (from-to)848-861
Number of pages14
JournalMedicinal Chemistry Research
Volume23
Issue number2
DOIs
StatePublished - Feb 2014

Fingerprint

Quantitative Structure-Activity Relationship
Niacin
Gram-Positive Bacteria
Structure-Activity Relationship
Anti-Infective Agents
Gram-Negative Bacteria
Pneumonia
Bacteria
Fungi
Escherichia coli
Bioactivity
1,2,4-triazole
In Vitro Techniques
anthranilic acid

Keywords

  • 1,2,4-Triazoles
  • Antibacterial
  • Antifungal
  • Pyridine
  • QSAR
  • Quinazoline

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

Cite this

Synthesis and QSAR studies of some novel disubstituted 1,2,4-triazoles as antimicrobial agents. / Panda, Siva S.

In: Medicinal Chemistry Research, Vol. 23, No. 2, 02.2014, p. 848-861.

Research output: Contribution to journalArticle

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