Synthesis and receptor binding of N-substituted-2-styryl-1,2,3,6-tetrahydropyridines as potential nicotinic agonists

J. Warren Beach, Christopher R. McCurdy, Mahanandeeshwar Gattu, Kenneth L. Boss, Roger E. Templeton, Alvin V Terry

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The synthesis of a series of N-substituted styryl-tetrahydropyridine derivatives is reported. The biological activity of these compounds was evaluated in vitro against both nicotinic and muscarinic receptors derived from rat cerebral cortex. The methyl derivative 6a shows binding affinity for central nicotinic receptors in the micromolar range.

Original languageEnglish (US)
Pages (from-to)271-281
Number of pages11
JournalMedicinal Chemistry Research
Volume7
Issue number5
StatePublished - Dec 1 1997

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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