Synthesis and receptor binding of N-substituted-2-styryl-1,2,3,6-tetrahydropyridines as potential nicotinic agonists

J. Warren Beach, Christopher R. McCurdy, Mahanandeeshwar Gattu, Kenneth L. Boss, Roger E. Templeton, Alvin V Terry

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The synthesis of a series of N-substituted styryl-tetrahydropyridine derivatives is reported. The biological activity of these compounds was evaluated in vitro against both nicotinic and muscarinic receptors derived from rat cerebral cortex. The methyl derivative 6a shows binding affinity for central nicotinic receptors in the micromolar range.

Original languageEnglish (US)
Pages (from-to)271-281
Number of pages11
JournalMedicinal Chemistry Research
Volume7
Issue number5
StatePublished - Dec 1 1997

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Nicotinic Agonists
Nicotinic Receptors
Derivatives
Muscarinic Receptors
Bioactivity
Cerebral Cortex
Rats
In Vitro Techniques

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

Cite this

Synthesis and receptor binding of N-substituted-2-styryl-1,2,3,6-tetrahydropyridines as potential nicotinic agonists. / Beach, J. Warren; McCurdy, Christopher R.; Gattu, Mahanandeeshwar; Boss, Kenneth L.; Templeton, Roger E.; Terry, Alvin V.

In: Medicinal Chemistry Research, Vol. 7, No. 5, 01.12.1997, p. 271-281.

Research output: Contribution to journalArticle

Beach, J. Warren ; McCurdy, Christopher R. ; Gattu, Mahanandeeshwar ; Boss, Kenneth L. ; Templeton, Roger E. ; Terry, Alvin V. / Synthesis and receptor binding of N-substituted-2-styryl-1,2,3,6-tetrahydropyridines as potential nicotinic agonists. In: Medicinal Chemistry Research. 1997 ; Vol. 7, No. 5. pp. 271-281.
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