The synthesis of a series of N-substituted styryl-tetrahydropyridine derivatives is reported. The biological activity of these compounds was evaluated in vitro against both nicotinic and muscarinic receptors derived from rat cerebral cortex. The methyl derivative 6a shows binding affinity for central nicotinic receptors in the micromolar range.
|Original language||English (US)|
|Number of pages||11|
|Journal||Medicinal Chemistry Research|
|State||Published - 1997|
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Organic Chemistry