Synthesis and selective cytotoxicity of novel biphenyl-based tetrazole derivatives

Mahesh H. Malani, Bharatkumar Z. Dholakiya, Ahmed Salah Ibrahim, Farid A. Badria

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cancer today represents a significant public health problem worldwide, and the challenge is to produce cost-effective drugs. Recently, biphenyl compounds as well as tetrazole derivatives is known for their potential nonselective anticancer activities. In search of novel selective anticancer agents, a series of newly hybrid molecules was designed and synthesized by combining the structural features of biphenyl and tetrazole moieties. The structures of newly synthesized compounds were characterized using spectroscopic techniques (FT-IR, 1H NMR, 13C NMR, and HMBC). Cytotoxic evaluations of these novels compound on human cancer cell lines showed a significant anticancer activity against more than one tested cell lines. Compounds 5n, 5j, and 5o proved to exhibit the strongest and selective cytotoxic effect on HepG2 and MCF-7 lines. Taken together, this study has led to the development of promising leads for cancer therapy.

Original languageEnglish (US)
Pages (from-to)4427-4435
Number of pages9
JournalMedicinal Chemistry Research
Volume23
Issue number10
DOIs
StatePublished - Oct 1 2014
Externally publishedYes

Fingerprint

Cytotoxicity
Biphenyl Compounds
Cells
Nuclear magnetic resonance
Derivatives
Public health
Medical problems
Antineoplastic Agents
Cell Line
Neoplasms
Drug Costs
Molecules
Public Health
Pharmaceutical Preparations
Costs
1H-tetrazole
diphenyl
Therapeutics

Keywords

  • Antiproliferative
  • Cancer
  • Chemotherapy
  • Cytotoxity
  • Tetrazole

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

Cite this

Synthesis and selective cytotoxicity of novel biphenyl-based tetrazole derivatives. / Malani, Mahesh H.; Dholakiya, Bharatkumar Z.; Ibrahim, Ahmed Salah; Badria, Farid A.

In: Medicinal Chemistry Research, Vol. 23, No. 10, 01.10.2014, p. 4427-4435.

Research output: Contribution to journalArticle

Malani, Mahesh H. ; Dholakiya, Bharatkumar Z. ; Ibrahim, Ahmed Salah ; Badria, Farid A. / Synthesis and selective cytotoxicity of novel biphenyl-based tetrazole derivatives. In: Medicinal Chemistry Research. 2014 ; Vol. 23, No. 10. pp. 4427-4435.
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