Synthesis, DNA binding and antiproliferative activity of ternary copper complexes of moxifloxacin and gatifloxacin against lung cancer cells

Rinky Singh, Ravirajsinh N. Jadeja, Menaka Thounaojam, Tushar Patel, Ranjitsinh V. Devkar, Debjani Chakraborty

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Mixed ligand Cu(II) complexes of third generation fluoroquinolone antibacterial agents moxifloxacin (MFL) and gatifloxacin (GFL) have been synthesized and characterized spectroscopically. The complexes have been found to bind DNA by intercalative mode and the DNA binding constants K b and K sv have been determined by absorption measurements and florescence quenching experiments respectively. The anti-proliferative and apoptosis inducing activity of the mixed ligand copper complexes against human lung carcinoma cells(A-549) was determined adopting MTT-assay, other specific staining techniques and DNA ladder. All the complexes have been shown to be cytotoxic towards A549 lung cancer cells. The complexes have been shown to bring about apoptosis of the cancerous cells.

Original languageEnglish (US)
Pages (from-to)78-84
Number of pages7
JournalInorganic Chemistry Communications
Volume23
DOIs
StatePublished - Sep 1 2012
Externally publishedYes

Fingerprint

lungs
Copper
DNA
deoxyribonucleic acid
cancer
Cells
apoptosis
Cell death
copper
synthesis
Ligands
Apoptosis
Bactericides
ligands
Fluoroquinolones
Ladders
staining
ladders
Quenching
Assays

Keywords

  • Apoptosis
  • Copper-complex
  • DNA binding
  • Gatifloxacin
  • Moxifloxacin

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

Cite this

Synthesis, DNA binding and antiproliferative activity of ternary copper complexes of moxifloxacin and gatifloxacin against lung cancer cells. / Singh, Rinky; Jadeja, Ravirajsinh N.; Thounaojam, Menaka; Patel, Tushar; Devkar, Ranjitsinh V.; Chakraborty, Debjani.

In: Inorganic Chemistry Communications, Vol. 23, 01.09.2012, p. 78-84.

Research output: Contribution to journalArticle

Singh, Rinky ; Jadeja, Ravirajsinh N. ; Thounaojam, Menaka ; Patel, Tushar ; Devkar, Ranjitsinh V. ; Chakraborty, Debjani. / Synthesis, DNA binding and antiproliferative activity of ternary copper complexes of moxifloxacin and gatifloxacin against lung cancer cells. In: Inorganic Chemistry Communications. 2012 ; Vol. 23. pp. 78-84.
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