Synthesis, DNA binding and antiproliferative activity of ternary copper complexes of moxifloxacin and gatifloxacin against lung cancer cells

Rinky Singh, Ravirajsinh N. Jadeja, Menaka C. Thounaojam, Tushar Patel, Ranjitsinh V. Devkar, Debjani Chakraborty

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Mixed ligand Cu(II) complexes of third generation fluoroquinolone antibacterial agents moxifloxacin (MFL) and gatifloxacin (GFL) have been synthesized and characterized spectroscopically. The complexes have been found to bind DNA by intercalative mode and the DNA binding constants K b and K sv have been determined by absorption measurements and florescence quenching experiments respectively. The anti-proliferative and apoptosis inducing activity of the mixed ligand copper complexes against human lung carcinoma cells(A-549) was determined adopting MTT-assay, other specific staining techniques and DNA ladder. All the complexes have been shown to be cytotoxic towards A549 lung cancer cells. The complexes have been shown to bring about apoptosis of the cancerous cells.

Original languageEnglish (US)
Pages (from-to)78-84
Number of pages7
JournalInorganic Chemistry Communications
Volume23
DOIs
StatePublished - Sep 1 2012

Keywords

  • Apoptosis
  • Copper-complex
  • DNA binding
  • Gatifloxacin
  • Moxifloxacin

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Synthesis, DNA binding and antiproliferative activity of ternary copper complexes of moxifloxacin and gatifloxacin against lung cancer cells'. Together they form a unique fingerprint.

  • Cite this