Synthesis of 4H-3-aryl-2-cyano-1,4-benzothiazine 1,1-dioxides for antiviral studies

Phillip D. Wilkerson, Andrew C. Bean, Chad E. Stephens

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations

    Abstract

    2-Cyano-substituted 1,4-benzothiazine 1,1-dioxides, required for antiviral studies, were prepared by a reductive cyclodehydration of an ortho-nitro sulfone precursor containing a pendant aryl ketone group. The ring-forming reaction also furnishes a non-cyclized benzamide as a major byproduct via an unexpected acyl transfer reaction.

    Original languageEnglish (US)
    Pages (from-to)101-103
    Number of pages3
    JournalHeterocyclic Communications
    Volume23
    Issue number2
    DOIs
    StatePublished - Apr 1 2017

    Keywords

    • 1,4-benzothiazine
    • acyl transfer
    • antiviral sulfone
    • cyclodehydration
    • iron reduction

    ASJC Scopus subject areas

    • Organic Chemistry

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