Synthesis of 4H-3-aryl-2-cyano-1,4-benzothiazine 1,1-dioxides for antiviral studies

Phillip D. Wilkerson, Andrew C. Bean, Chad E. Stephens

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

2-Cyano-substituted 1,4-benzothiazine 1,1-dioxides, required for antiviral studies, were prepared by a reductive cyclodehydration of an ortho-nitro sulfone precursor containing a pendant aryl ketone group. The ring-forming reaction also furnishes a non-cyclized benzamide as a major byproduct via an unexpected acyl transfer reaction.

Original languageEnglish (US)
Pages (from-to)101-103
Number of pages3
JournalHeterocyclic Communications
Volume23
Issue number2
DOIs
StatePublished - Apr 1 2017

Fingerprint

Sulfones
Ketones
Antiviral Agents
Byproducts
1,4-benzothiazine
benzamide

Keywords

  • 1,4-benzothiazine
  • acyl transfer
  • antiviral sulfone
  • cyclodehydration
  • iron reduction

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Synthesis of 4H-3-aryl-2-cyano-1,4-benzothiazine 1,1-dioxides for antiviral studies. / Wilkerson, Phillip D.; Bean, Andrew C.; Stephens, Chad E.

In: Heterocyclic Communications, Vol. 23, No. 2, 01.04.2017, p. 101-103.

Research output: Contribution to journalArticle

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