Abstract
2-Cyano-substituted 1,4-benzothiazine 1,1-dioxides, required for antiviral studies, were prepared by a reductive cyclodehydration of an ortho-nitro sulfone precursor containing a pendant aryl ketone group. The ring-forming reaction also furnishes a non-cyclized benzamide as a major byproduct via an unexpected acyl transfer reaction.
Original language | English (US) |
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Pages (from-to) | 101-103 |
Number of pages | 3 |
Journal | Heterocyclic Communications |
Volume | 23 |
Issue number | 2 |
DOIs | |
State | Published - Apr 1 2017 |
Keywords
- 1,4-benzothiazine
- acyl transfer
- antiviral sulfone
- cyclodehydration
- iron reduction
ASJC Scopus subject areas
- Organic Chemistry