TY - JOUR
T1 - Synthesis of antimicrobial silsesquioxane-silica hybrids by hydrolytic co-condensation of alkoxysilanes
AU - Gong, Shi Qiang
AU - Epasinghe, D. Jeevanie
AU - Zhang, Wei
AU - Zhou, Bin
AU - Niu, Li Na
AU - Ryou, Heonjune
AU - Eid, Ashraf A.
AU - Frassetto, Andrea
AU - Yiu, Cynthia K.Y.
AU - Arola, Dwayne D.
AU - Mao, Jing
AU - Pashley, David Henry
AU - Tay, Franklin Chi Meng
PY - 2014/1/21
Y1 - 2014/1/21
N2 - Organically modified silicates represent an excellent example of organic-inorganic hybrids in materials science. The routes to achieve incorporation of organic functionalities include grafting and co-condensation (one-pot synthesis). Compared with the grafting method, the advantage of one-pot synthesis manifests as the tunability of both mechanical and biological properties. Herein, we report a silsesquioxane-silica hybrid (SqSH) with dual functional groups (alkylammonium and methacrylate chains) synthesized by the hydrolytic co-condensation of one tetraethoxysilane and two alkoxysilanes. Successful co-condensation is validated by attenuated total reflection-Fourier transform infrared (ATR-FTIR), 29Si nuclear magnetic resonance ( 29Si NMR), and thermogravimetric analysis (TGA). 3-(Trimethoxysilyl) propyldimethyloctadecyl ammonium chloride (SiQAC), one of the three precursors, simultaneously serves as a structure-directing agent in the modified Stöber reaction, resulting in SqSH particles with structural hierarchy of both ordered lamellar structure and spherical morphology, as revealed by X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The SqSH particles bear tunable mechanical properties and, when incorporated into bis-GMA/TEGDMA resin, antimicrobial activities against Streptococcus mutans, Actinomyces naeslundii, and Candida albicans.
AB - Organically modified silicates represent an excellent example of organic-inorganic hybrids in materials science. The routes to achieve incorporation of organic functionalities include grafting and co-condensation (one-pot synthesis). Compared with the grafting method, the advantage of one-pot synthesis manifests as the tunability of both mechanical and biological properties. Herein, we report a silsesquioxane-silica hybrid (SqSH) with dual functional groups (alkylammonium and methacrylate chains) synthesized by the hydrolytic co-condensation of one tetraethoxysilane and two alkoxysilanes. Successful co-condensation is validated by attenuated total reflection-Fourier transform infrared (ATR-FTIR), 29Si nuclear magnetic resonance ( 29Si NMR), and thermogravimetric analysis (TGA). 3-(Trimethoxysilyl) propyldimethyloctadecyl ammonium chloride (SiQAC), one of the three precursors, simultaneously serves as a structure-directing agent in the modified Stöber reaction, resulting in SqSH particles with structural hierarchy of both ordered lamellar structure and spherical morphology, as revealed by X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The SqSH particles bear tunable mechanical properties and, when incorporated into bis-GMA/TEGDMA resin, antimicrobial activities against Streptococcus mutans, Actinomyces naeslundii, and Candida albicans.
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U2 - 10.1039/c3py00635b
DO - 10.1039/c3py00635b
M3 - Article
AN - SCOPUS:84890500072
SN - 1759-9954
VL - 5
SP - 454
EP - 462
JO - Polymer Chemistry
JF - Polymer Chemistry
IS - 2
ER -