Synthesis of antimicrobial silsesquioxane-silica hybrids by hydrolytic co-condensation of alkoxysilanes

Shi Qiang Gong, D. Jeevanie Epasinghe, Wei Zhang, Bin Zhou, Li Na Niu, Heonjune Ryou, Ashraf A. Eid, Andrea Frassetto, Cynthia K.Y. Yiu, Dwayne D. Arola, Jing Mao, David Henry Pashley, Franklin Chi Meng Tay

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Organically modified silicates represent an excellent example of organic-inorganic hybrids in materials science. The routes to achieve incorporation of organic functionalities include grafting and co-condensation (one-pot synthesis). Compared with the grafting method, the advantage of one-pot synthesis manifests as the tunability of both mechanical and biological properties. Herein, we report a silsesquioxane-silica hybrid (SqSH) with dual functional groups (alkylammonium and methacrylate chains) synthesized by the hydrolytic co-condensation of one tetraethoxysilane and two alkoxysilanes. Successful co-condensation is validated by attenuated total reflection-Fourier transform infrared (ATR-FTIR), 29Si nuclear magnetic resonance ( 29Si NMR), and thermogravimetric analysis (TGA). 3-(Trimethoxysilyl) propyldimethyloctadecyl ammonium chloride (SiQAC), one of the three precursors, simultaneously serves as a structure-directing agent in the modified Stöber reaction, resulting in SqSH particles with structural hierarchy of both ordered lamellar structure and spherical morphology, as revealed by X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The SqSH particles bear tunable mechanical properties and, when incorporated into bis-GMA/TEGDMA resin, antimicrobial activities against Streptococcus mutans, Actinomyces naeslundii, and Candida albicans.

Original languageEnglish (US)
Pages (from-to)454-462
Number of pages9
JournalPolymer Chemistry
Volume5
Issue number2
DOIs
StatePublished - Jan 21 2014

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Polymers and Plastics
  • Organic Chemistry

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    Gong, S. Q., Epasinghe, D. J., Zhang, W., Zhou, B., Niu, L. N., Ryou, H., Eid, A. A., Frassetto, A., Yiu, C. K. Y., Arola, D. D., Mao, J., Pashley, D. H., & Tay, F. C. M. (2014). Synthesis of antimicrobial silsesquioxane-silica hybrids by hydrolytic co-condensation of alkoxysilanes. Polymer Chemistry, 5(2), 454-462. https://doi.org/10.1039/c3py00635b