Synthesis of deuterium-labelled 2,5-bis(4-amidinophenyl)furan, 2,5-bis[4-(methoxyamidino)phenyl]furan, and 2,7-diamidinocarbazole

Chad E. Stephens; Donald A. Patrick; Heidi Chen; Richard R. Tidwell; David W. Boykin

doi:10.1002/jlcr.444

Synthesis of deuterium-labelled 2,5-bis(4-amidinophenyl)furan, 2,5-bis[4-(methoxyamidino)phenyl]furan, and 2,7-diamidinocarbazole

Chad E. Stephens, Donald A. Patrick, Heidi Chen, Richard R. Tidwell, David W. Boykin

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The syntheses of 2,5-bis(4-amidinophenyl)furan-d₈ (1-d₈) and 2,5-bis[4-(methoxyamidino)phenyl]furan-d₈ (2-d₈) from bromobenzene-d₅ in six steps, and of 2,7-diamidinocarbazole-d₆ (3-d₆) from biphenyl-d₁₀ in five steps, are described.

Original language	English (US)
Pages (from-to)	197-208
Number of pages	12
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	44
Issue number	3
DOIs	https://doi.org/10.1002/jlcr.444
State	Published - Mar 19 2001
Externally published	Yes

Keywords

2,5-bis(4-amidinophenyl)furan-d
2,5-bis[4- (methoxyamidino)phenyl]furan-d
2,7-diamidinocarbazole- d
Antimicrobial
Deuterium-labelled
Prodrug

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

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10.1002/jlcr.444

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title = "Synthesis of deuterium-labelled 2,5-bis(4-amidinophenyl)furan, 2,5-bis[4-(methoxyamidino)phenyl]furan, and 2,7-diamidinocarbazole",

abstract = "The syntheses of 2,5-bis(4-amidinophenyl)furan-d8 (1-d8) and 2,5-bis[4-(methoxyamidino)phenyl]furan-d8 (2-d8) from bromobenzene-d5 in six steps, and of 2,7-diamidinocarbazole-d6 (3-d6) from biphenyl-d10 in five steps, are described.",

keywords = "2,5-bis(4-amidinophenyl)furan-d, 2,5-bis[4- (methoxyamidino)phenyl]furan-d, 2,7-diamidinocarbazole- d, Antimicrobial, Deuterium-labelled, Prodrug",

author = "Stephens, {Chad E.} and Patrick, {Donald A.} and Heidi Chen and Tidwell, {Richard R.} and Boykin, {David W.}",

year = "2001",

month = mar,

day = "19",

doi = "10.1002/jlcr.444",

language = "English (US)",

volume = "44",

pages = "197--208",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

issn = "0362-4803",

publisher = "John Wiley and Sons Ltd",

number = "3",

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TY - JOUR

T1 - Synthesis of deuterium-labelled 2,5-bis(4-amidinophenyl)furan, 2,5-bis[4-(methoxyamidino)phenyl]furan, and 2,7-diamidinocarbazole

AU - Stephens, Chad E.

AU - Patrick, Donald A.

AU - Chen, Heidi

AU - Tidwell, Richard R.

AU - Boykin, David W.

PY - 2001/3/19

Y1 - 2001/3/19

N2 - The syntheses of 2,5-bis(4-amidinophenyl)furan-d8 (1-d8) and 2,5-bis[4-(methoxyamidino)phenyl]furan-d8 (2-d8) from bromobenzene-d5 in six steps, and of 2,7-diamidinocarbazole-d6 (3-d6) from biphenyl-d10 in five steps, are described.

AB - The syntheses of 2,5-bis(4-amidinophenyl)furan-d8 (1-d8) and 2,5-bis[4-(methoxyamidino)phenyl]furan-d8 (2-d8) from bromobenzene-d5 in six steps, and of 2,7-diamidinocarbazole-d6 (3-d6) from biphenyl-d10 in five steps, are described.

KW - 2,5-bis(4-amidinophenyl)furan-d

KW - 2,5-bis[4- (methoxyamidino)phenyl]furan-d

KW - 2,7-diamidinocarbazole- d

KW - Antimicrobial

KW - Deuterium-labelled

KW - Prodrug

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U2 - 10.1002/jlcr.444

DO - 10.1002/jlcr.444

M3 - Article

AN - SCOPUS:0035101948

SN - 0362-4803

VL - 44

SP - 197

EP - 208

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 3

ER -

Synthesis of deuterium-labelled 2,5-bis(4-amidinophenyl)furan, 2,5-bis[4-(methoxyamidino)phenyl]furan, and 2,7-diamidinocarbazole

Abstract

Keywords

ASJC Scopus subject areas

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