Synthesis of deuterium-labelled 2,5-bis(4-amidinophenyl)furan, 2,5-bis[4-(methoxyamidino)phenyl]furan, and 2,7-diamidinocarbazole

Chad E. Stephens, Donald A. Patrick, Heidi Chen, Richard R. Tidwell, David W. Boykin

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The syntheses of 2,5-bis(4-amidinophenyl)furan-d8 (1-d8) and 2,5-bis[4-(methoxyamidino)phenyl]furan-d8 (2-d8) from bromobenzene-d5 in six steps, and of 2,7-diamidinocarbazole-d6 (3-d6) from biphenyl-d10 in five steps, are described.

Original languageEnglish (US)
Pages (from-to)197-208
Number of pages12
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume44
Issue number3
DOIs
StatePublished - Mar 19 2001

Keywords

  • 2,5-bis(4-amidinophenyl)furan-d
  • 2,5-bis[4- (methoxyamidino)phenyl]furan-d
  • 2,7-diamidinocarbazole- d
  • Antimicrobial
  • Deuterium-labelled
  • Prodrug

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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