Synthesis of l-lys-aminoxy-goralatide

Zhiliang Li, Iryna Oleksandrivna Lebedyeva, Deqian Zhao, Lauren Myers, Girinath G. Pillai, Charles Dennis Hall, Alan R. Katritzky

Research output: Contribution to journalArticle

Abstract

Natural tetrapeptide Goralatide inhibits primitive hematopoietic cell proliferation but reported to be rather unstable in solution (half-life 4.5 min). In this work, we report the synthesis of an aminoxy analog of Goralatide. Aminoxy moiety is expected to provide increased stability and bioavailability of the Goralatide analog.

Original languageEnglish (US)
Pages (from-to)923-927
Number of pages5
JournalJournal of Peptide Science
Volume20
Issue number12
DOIs
StatePublished - Oct 20 2014

Keywords

  • Acylation
  • Coupling
  • Goralatide
  • Peptides
  • Peptidomimetics

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Li, Z., Lebedyeva, I. O., Zhao, D., Myers, L., Pillai, G. G., Hall, C. D., & Katritzky, A. R. (2014). Synthesis of l-lys-aminoxy-goralatide. Journal of Peptide Science, 20(12), 923-927. https://doi.org/10.1002/psc.2702