Synthesis of l-lys-aminoxy-goralatide

Zhiliang Li, Iryna Oleksandrivna Lebedyeva, Deqian Zhao, Lauren Myers, Girinath G. Pillai, Charles Dennis Hall, Alan R. Katritzky

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Natural tetrapeptide Goralatide inhibits primitive hematopoietic cell proliferation but reported to be rather unstable in solution (half-life 4.5 min). In this work, we report the synthesis of an aminoxy analog of Goralatide. Aminoxy moiety is expected to provide increased stability and bioavailability of the Goralatide analog.

    Original languageEnglish (US)
    Pages (from-to)923-927
    Number of pages5
    JournalJournal of Peptide Science
    Volume20
    Issue number12
    DOIs
    StatePublished - Oct 20 2014

    Keywords

    • Acylation
    • Coupling
    • Goralatide
    • Peptides
    • Peptidomimetics

    ASJC Scopus subject areas

    • Structural Biology
    • Biochemistry
    • Molecular Medicine
    • Molecular Biology
    • Pharmacology
    • Drug Discovery
    • Organic Chemistry

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