Abstract
Natural tetrapeptide Goralatide inhibits primitive hematopoietic cell proliferation but reported to be rather unstable in solution (half-life 4.5 min). In this work, we report the synthesis of an aminoxy analog of Goralatide. Aminoxy moiety is expected to provide increased stability and bioavailability of the Goralatide analog.
Original language | English (US) |
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Pages (from-to) | 923-927 |
Number of pages | 5 |
Journal | Journal of Peptide Science |
Volume | 20 |
Issue number | 12 |
DOIs | |
State | Published - Oct 20 2014 |
Keywords
- Acylation
- Coupling
- Goralatide
- Peptides
- Peptidomimetics
ASJC Scopus subject areas
- Structural Biology
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmacology
- Drug Discovery
- Organic Chemistry