@article{4a7a3b54a4ec4daa8c8c7148f14ba3c7,
title = "Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach",
abstract = "We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 virus were investigated and their cytotoxicity was also determined. Among all the synthesized conjugates, compound 9f showed potential against SARS-CoV-2 and low cytotoxicity. The conjugates{\textquoteright} selectivity indexes (SIs) were determined to correlate the antiviral properties and cytotoxicity. The observed biological data were further validated using computational studies.",
keywords = "SARS-CoV-2, healthcare, indole, molecular modeling, quinoline, rhodanine",
author = "Wyman, {Kailey A.} and Girgis, {Adel S.} and Surapaneni, {Pragnakiran S.} and Moore, {Jade M.} and {Abo Shama}, {Noura M.} and Mahmoud, {Sara H.} and Ahmed Mostafa and Barghash, {Reham F.} and Zou Juan and Dobaria, {Radha D.} and Almalki, {Ahmad J.} and Ibrahim, {Tarek S.} and Panda, {Siva S.}",
note = "Funding Information: We thank the Augusta University Provost{\textquoteright}s office, the Translational Research Program of the Department of Medicine, Medical College of Georgia at Augusta University, and the Undergraduate Research and Scholarship (CURS), Augusta University for their support. The authors also thanks Maria Sabbatini and Shogo Mori for their valuable suggestions. Funding Information: The Deanship of Scientific Research (DSR) at King Abdulaziz University (KAU), Jeddah, Saudi Arabia funded this project under grant number (RG-34–166–43). The authors, therefore, gratefully acknowledge DSR technical and financial support. Publisher Copyright: {\textcopyright} 2022 by the authors.",
year = "2022",
month = sep,
doi = "10.3390/molecules27185923",
language = "English (US)",
volume = "27",
journal = "Molecules",
issn = "1420-3049",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "18",
}