Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach

Kailey A. Wyman, Adel S. Girgis, Pragnakiran S. Surapaneni, Jade M. Moore, Noura M. Abo Shama, Sara H. Mahmoud, Ahmed Mostafa, Reham F. Barghash, Zou Juan, Radha D. Dobaria, Ahmad J. Almalki, Tarek S. Ibrahim, Siva S. Panda

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 virus were investigated and their cytotoxicity was also determined. Among all the synthesized conjugates, compound 9f showed potential against SARS-CoV-2 and low cytotoxicity. The conjugates’ selectivity indexes (SIs) were determined to correlate the antiviral properties and cytotoxicity. The observed biological data were further validated using computational studies.

Original languageEnglish (US)
Article number5923
JournalMolecules
Volume27
Issue number18
DOIs
StatePublished - Sep 2022

Keywords

  • healthcare
  • indole
  • molecular modeling
  • quinoline
  • rhodanine
  • SARS-CoV-2

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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