Synthesis of saracatinib

Hai Feng Shang, Yu Bin Wang, Da Min Zhao, Qi Zhang, Jin-Xiong She

Research output: Contribution to journalArticle

Abstract

To synthesize the Src kinase inhibitor saracatinib, and optimize the synthetic process. Medthods: Saracatinib was synthesized from 2, 4, 6-trifluorobenzonitrile through procedures of ammonolysis, hydrolysis, cyclization, and substitution. Results and Conclusion: Saracatinib was synthesized with a total yield of 24.54%, and was verified by 1H-NMR and MS. This synthetic method was suitable for large-scale production.

Original languageEnglish (US)
Pages (from-to)2363-2366
Number of pages4
JournalChinese Journal of New Drugs
Volume20
Issue number23
StatePublished - Dec 15 2011
Externally publishedYes

Fingerprint

src-Family Kinases
Cyclization
Hydrolysis
saracatinib
Proton Magnetic Resonance Spectroscopy

Keywords

  • Saracatinib
  • Synthesis
  • Tyrosine kinase inhibitor

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

Shang, H. F., Wang, Y. B., Zhao, D. M., Zhang, Q., & She, J-X. (2011). Synthesis of saracatinib. Chinese Journal of New Drugs, 20(23), 2363-2366.

Synthesis of saracatinib. / Shang, Hai Feng; Wang, Yu Bin; Zhao, Da Min; Zhang, Qi; She, Jin-Xiong.

In: Chinese Journal of New Drugs, Vol. 20, No. 23, 15.12.2011, p. 2363-2366.

Research output: Contribution to journalArticle

Shang, HF, Wang, YB, Zhao, DM, Zhang, Q & She, J-X 2011, 'Synthesis of saracatinib', Chinese Journal of New Drugs, vol. 20, no. 23, pp. 2363-2366.
Shang HF, Wang YB, Zhao DM, Zhang Q, She J-X. Synthesis of saracatinib. Chinese Journal of New Drugs. 2011 Dec 15;20(23):2363-2366.
Shang, Hai Feng ; Wang, Yu Bin ; Zhao, Da Min ; Zhang, Qi ; She, Jin-Xiong. / Synthesis of saracatinib. In: Chinese Journal of New Drugs. 2011 ; Vol. 20, No. 23. pp. 2363-2366.
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