Synthesis of saracatinib

Hai Feng Shang; Yu Bin Wang; Da Min Zhao; Qi Zhang; Jin-Xiong She

Synthesis of saracatinib

Hai Feng Shang, Yu Bin Wang, Da Min Zhao, Qi Zhang, Jin-Xiong She

Research output: Contribution to journal › Article › peer-review

Abstract

To synthesize the Src kinase inhibitor saracatinib, and optimize the synthetic process. Medthods: Saracatinib was synthesized from 2, 4, 6-trifluorobenzonitrile through procedures of ammonolysis, hydrolysis, cyclization, and substitution. Results and Conclusion: Saracatinib was synthesized with a total yield of 24.54%, and was verified by ¹H-NMR and MS. This synthetic method was suitable for large-scale production.

Original language	English (US)
Pages (from-to)	2363-2366
Number of pages	4
Journal	Chinese Journal of New Drugs
Volume	20
Issue number	23
State	Published - Dec 15 2011
Externally published	Yes

Keywords

Saracatinib
Synthesis
Tyrosine kinase inhibitor

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
Pharmacology (medical)

Cite this

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title = "Synthesis of saracatinib",

abstract = "To synthesize the Src kinase inhibitor saracatinib, and optimize the synthetic process. Medthods: Saracatinib was synthesized from 2, 4, 6-trifluorobenzonitrile through procedures of ammonolysis, hydrolysis, cyclization, and substitution. Results and Conclusion: Saracatinib was synthesized with a total yield of 24.54%, and was verified by 1H-NMR and MS. This synthetic method was suitable for large-scale production.",

keywords = "Saracatinib, Synthesis, Tyrosine kinase inhibitor",

author = "Shang, {Hai Feng} and Wang, {Yu Bin} and Zhao, {Da Min} and Qi Zhang and Jin-Xiong She",

year = "2011",

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journal = "Chinese Journal of New Drugs",

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T1 - Synthesis of saracatinib

AU - Shang, Hai Feng

AU - Wang, Yu Bin

AU - Zhao, Da Min

AU - Zhang, Qi

AU - She, Jin-Xiong

PY - 2011/12/15

Y1 - 2011/12/15

N2 - To synthesize the Src kinase inhibitor saracatinib, and optimize the synthetic process. Medthods: Saracatinib was synthesized from 2, 4, 6-trifluorobenzonitrile through procedures of ammonolysis, hydrolysis, cyclization, and substitution. Results and Conclusion: Saracatinib was synthesized with a total yield of 24.54%, and was verified by 1H-NMR and MS. This synthetic method was suitable for large-scale production.

AB - To synthesize the Src kinase inhibitor saracatinib, and optimize the synthetic process. Medthods: Saracatinib was synthesized from 2, 4, 6-trifluorobenzonitrile through procedures of ammonolysis, hydrolysis, cyclization, and substitution. Results and Conclusion: Saracatinib was synthesized with a total yield of 24.54%, and was verified by 1H-NMR and MS. This synthetic method was suitable for large-scale production.

KW - Saracatinib

KW - Synthesis

KW - Tyrosine kinase inhibitor

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AN - SCOPUS:84859491993

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Synthesis of saracatinib

Abstract

Keywords

ASJC Scopus subject areas

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