Synthetic approaches to 2-arylbenzimidazoles: A review

Siva S. Panda, Ritu Malik, Subhash C. Jain

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations

Abstract

Benzimidazoles are very useful building blocks for the development of molecules that are important in medicinal chemistry. 2- Substituted benzimidazole derivatives have found applications as diverse therapeutic agents, including antiulcers, antihypertensives, antivirals, antifungals, anticancers, and antihistaminics. Because of their importance, the methods for their synthesis have become a focus of Synthetic Organic Chemists. However, we failed to locate report in the literature that covers various efforts that have been made for the synthesis of 2-arylbenzimidazoles. Therefore, in the present review, we have tried to compile some of the important synthetic techniques and methodologies used for its synthesis during the last decade.

Original languageEnglish (US)
Pages (from-to)1905-1919
Number of pages15
JournalCurrent Organic Chemistry
Volume16
Issue number16
DOIs
StatePublished - 2012
Externally publishedYes

Keywords

  • 2-Arylbenzimidazoles
  • Methodologies
  • O-phenylenediamine
  • Synthetic routes

ASJC Scopus subject areas

  • Organic Chemistry

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