Systems Genetics Reveals the Functional Context of PCOS Loci and Identifies Genetic and Molecular Mechanisms of Disease Heterogeneity

Earth & Environmental Sciences

• gene expression 70%
• androgen 63%
• woman 57%
• methylation 53%
• polymorphism 31%
• gene 22%
• tissue 21%
• obesity 19%
• genetic variation 18%
• secretion 15%
• genome 14%
• DNA 12%
• regulation 10%
• young 10%
• analysis 3%

Medicine & Life Sciences

• Genetic Loci 73%
• Polycystic Ovary Syndrome 67%
• Molecular Biology 48%
• Androgens 18%
• Methylation 12%
• Gene Expression 12%
• Ovary 11%
• Single Nucleotide Polymorphism 11%
• Oligomenorrhea 9%
• LH Receptors 9%
• Insulin Receptor 7%
• Subcutaneous Fat 7%
• Genome-Wide Association Study 6%
• DNA Methylation 6%
• Genetic Variation 6%
• Vascular Resistance 6%
• Transcriptome 6%
• Epigenomics 5%
• Insulin Resistance 5%
• Genes 5%
• Obesity 4%
• Biopsy 4%

Agriculture & Biology

• polycystic ovary syndrome 100%
• loci 36%
• androgens 20%
• gene expression 16%
• methylation 12%
• single nucleotide polymorphism 12%
• insulin receptors 9%
• insulin resistance 8%
• genome-wide association study 7%
• DNA methylation 7%
• obesity 6%
• biopsy 6%
• adipose tissue 6%
• epigenetics 6%
• secretion 4%
• genes 4%
• receptors 4%
• genetic variation 4%
• tissues 2%