T-cell involvement in sex differences in blood pressure control

G. Ryan Crislip, Jennifer C Sullivan

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Hypertension affects one-third of adults in the Western world and is the most common independent risk factor for cardiovascular disease, and the leading cause of premature death globally. Despite available therapeutic options, approximately half of the hypertensive population taking medication does not achieve adequate blood pressure (BP) control leaving them at increased risk of chronic kidney disease, renal failure, stroke, congestive heart failure, myocardial infarction, aneurysm and peripheral artery disease. New therapeutic options need to be identified for the treatment of hypertension in order to increase the percentage of individuals with controlled BP. There is a growing basic science literature regarding the role of T-cells in the pathogenesis of hypertension and BP control; however, the majority of this literature has been performed exclusively in males despite the fact that both men and women develop hypertension. This is especially problematic since hypertension is well recognized as having distinct sex differences in the prevalence, absolute BP values and molecular mechanisms contributing to the pathophysiology of the disease. The purpose of this article is to review the available literature regarding sex differences in T-cells in hypertension followed by highlighting the potential pathways that may result in sex-specific effects on T-cell activation and differentiation.

Original languageEnglish (US)
Pages (from-to)773-783
Number of pages11
JournalClinical Science
Volume130
Issue number10
DOIs
StatePublished - May 1 2016

Fingerprint

Sex Characteristics
Blood Pressure
Hypertension
T-Lymphocytes
Western World
Premature Mortality
Peripheral Arterial Disease
Chronic Renal Insufficiency
Renal Insufficiency
Aneurysm
Cell Differentiation
Cause of Death
Cardiovascular Diseases
Therapeutics
Heart Failure
Stroke
Myocardial Infarction
Population

Keywords

  • Angiotensin
  • Blood pressure regulation
  • Inflammation
  • Sex differences
  • T regulatory cell
  • Th17 cell

ASJC Scopus subject areas

  • Medicine(all)

Cite this

T-cell involvement in sex differences in blood pressure control. / Crislip, G. Ryan; Sullivan, Jennifer C.

In: Clinical Science, Vol. 130, No. 10, 01.05.2016, p. 773-783.

Research output: Contribution to journalReview article

@article{20beabf07a53479c8add8dc7c7e330cc,
title = "T-cell involvement in sex differences in blood pressure control",
abstract = "Hypertension affects one-third of adults in the Western world and is the most common independent risk factor for cardiovascular disease, and the leading cause of premature death globally. Despite available therapeutic options, approximately half of the hypertensive population taking medication does not achieve adequate blood pressure (BP) control leaving them at increased risk of chronic kidney disease, renal failure, stroke, congestive heart failure, myocardial infarction, aneurysm and peripheral artery disease. New therapeutic options need to be identified for the treatment of hypertension in order to increase the percentage of individuals with controlled BP. There is a growing basic science literature regarding the role of T-cells in the pathogenesis of hypertension and BP control; however, the majority of this literature has been performed exclusively in males despite the fact that both men and women develop hypertension. This is especially problematic since hypertension is well recognized as having distinct sex differences in the prevalence, absolute BP values and molecular mechanisms contributing to the pathophysiology of the disease. The purpose of this article is to review the available literature regarding sex differences in T-cells in hypertension followed by highlighting the potential pathways that may result in sex-specific effects on T-cell activation and differentiation.",
keywords = "Angiotensin, Blood pressure regulation, Inflammation, Sex differences, T regulatory cell, Th17 cell",
author = "Crislip, {G. Ryan} and Sullivan, {Jennifer C}",
year = "2016",
month = "5",
day = "1",
doi = "10.1042/CS20150620",
language = "English (US)",
volume = "130",
pages = "773--783",
journal = "Clinical Science",
issn = "0143-5221",
publisher = "Portland Press Ltd.",
number = "10",

}

TY - JOUR

T1 - T-cell involvement in sex differences in blood pressure control

AU - Crislip, G. Ryan

AU - Sullivan, Jennifer C

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Hypertension affects one-third of adults in the Western world and is the most common independent risk factor for cardiovascular disease, and the leading cause of premature death globally. Despite available therapeutic options, approximately half of the hypertensive population taking medication does not achieve adequate blood pressure (BP) control leaving them at increased risk of chronic kidney disease, renal failure, stroke, congestive heart failure, myocardial infarction, aneurysm and peripheral artery disease. New therapeutic options need to be identified for the treatment of hypertension in order to increase the percentage of individuals with controlled BP. There is a growing basic science literature regarding the role of T-cells in the pathogenesis of hypertension and BP control; however, the majority of this literature has been performed exclusively in males despite the fact that both men and women develop hypertension. This is especially problematic since hypertension is well recognized as having distinct sex differences in the prevalence, absolute BP values and molecular mechanisms contributing to the pathophysiology of the disease. The purpose of this article is to review the available literature regarding sex differences in T-cells in hypertension followed by highlighting the potential pathways that may result in sex-specific effects on T-cell activation and differentiation.

AB - Hypertension affects one-third of adults in the Western world and is the most common independent risk factor for cardiovascular disease, and the leading cause of premature death globally. Despite available therapeutic options, approximately half of the hypertensive population taking medication does not achieve adequate blood pressure (BP) control leaving them at increased risk of chronic kidney disease, renal failure, stroke, congestive heart failure, myocardial infarction, aneurysm and peripheral artery disease. New therapeutic options need to be identified for the treatment of hypertension in order to increase the percentage of individuals with controlled BP. There is a growing basic science literature regarding the role of T-cells in the pathogenesis of hypertension and BP control; however, the majority of this literature has been performed exclusively in males despite the fact that both men and women develop hypertension. This is especially problematic since hypertension is well recognized as having distinct sex differences in the prevalence, absolute BP values and molecular mechanisms contributing to the pathophysiology of the disease. The purpose of this article is to review the available literature regarding sex differences in T-cells in hypertension followed by highlighting the potential pathways that may result in sex-specific effects on T-cell activation and differentiation.

KW - Angiotensin

KW - Blood pressure regulation

KW - Inflammation

KW - Sex differences

KW - T regulatory cell

KW - Th17 cell

UR - http://www.scopus.com/inward/record.url?scp=84974588067&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84974588067&partnerID=8YFLogxK

U2 - 10.1042/CS20150620

DO - 10.1042/CS20150620

M3 - Review article

C2 - 27128802

AN - SCOPUS:84974588067

VL - 130

SP - 773

EP - 783

JO - Clinical Science

JF - Clinical Science

SN - 0143-5221

IS - 10

ER -