T cell regulatory plasmacytoid dendritic cells expressing indoleamine 2,3 dioxygenase

Andrew L. Mellor, David J. Kahler

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Mature dendritic cells (DCs) are potent stimulators of T cells that recognize antigens presented by the DCs. In this chapter we describe mature DCs that suppress T cell responses to antigens they present due to expression of the intracel-lular enzyme indoleamine 2,3 dioxygenase (IDO). IDO-competent DCs are a subset of plasmacytoid DCs that can be induced to express IDO under certain inflammatory conditions in humans and mice. Though rare, IDO-expressing DCs acquire potent T cell suppressor activity that may predominate over the T cell stimulatory functions of all other antigen-presenting cells in physiologic environments due in part, to cooperation with regulatory T cells. Thus, IDO-expressing DCs are critical regulators of adaptive immunity that contribute to a wide range of inflammatory disease processes. As such, manipulating IDO expression in DCs using IDO inhibitors or IDO inducers offers considerable opportunities to improve immunotherapies in a range of clinically-significant disease syndromes.

Original languageEnglish (US)
Pages (from-to)165-196
Number of pages32
JournalHandbook of Experimental Pharmacology
Volume188
DOIs
StatePublished - Jun 25 2009

Fingerprint

Indoleamine-Pyrrole 2,3,-Dioxygenase
T-cells
Regulatory T-Lymphocytes
Dendritic Cells
T-Lymphocytes
Antigens
Adaptive Immunity
Antigen-Presenting Cells
Immunotherapy

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry

Cite this

T cell regulatory plasmacytoid dendritic cells expressing indoleamine 2,3 dioxygenase. / Mellor, Andrew L.; Kahler, David J.

In: Handbook of Experimental Pharmacology, Vol. 188, 25.06.2009, p. 165-196.

Research output: Contribution to journalArticle

@article{ca191a74901b4b7b92251fa952536ace,
title = "T cell regulatory plasmacytoid dendritic cells expressing indoleamine 2,3 dioxygenase",
abstract = "Mature dendritic cells (DCs) are potent stimulators of T cells that recognize antigens presented by the DCs. In this chapter we describe mature DCs that suppress T cell responses to antigens they present due to expression of the intracel-lular enzyme indoleamine 2,3 dioxygenase (IDO). IDO-competent DCs are a subset of plasmacytoid DCs that can be induced to express IDO under certain inflammatory conditions in humans and mice. Though rare, IDO-expressing DCs acquire potent T cell suppressor activity that may predominate over the T cell stimulatory functions of all other antigen-presenting cells in physiologic environments due in part, to cooperation with regulatory T cells. Thus, IDO-expressing DCs are critical regulators of adaptive immunity that contribute to a wide range of inflammatory disease processes. As such, manipulating IDO expression in DCs using IDO inhibitors or IDO inducers offers considerable opportunities to improve immunotherapies in a range of clinically-significant disease syndromes.",
author = "Mellor, {Andrew L.} and Kahler, {David J.}",
year = "2009",
month = "6",
day = "25",
doi = "10.1007/978-3-540-71029-5-8",
language = "English (US)",
volume = "188",
pages = "165--196",
journal = "Handbook of Experimental Pharmacology",
issn = "0171-2004",
publisher = "Springer Heidelberg",

}

TY - JOUR

T1 - T cell regulatory plasmacytoid dendritic cells expressing indoleamine 2,3 dioxygenase

AU - Mellor, Andrew L.

AU - Kahler, David J.

PY - 2009/6/25

Y1 - 2009/6/25

N2 - Mature dendritic cells (DCs) are potent stimulators of T cells that recognize antigens presented by the DCs. In this chapter we describe mature DCs that suppress T cell responses to antigens they present due to expression of the intracel-lular enzyme indoleamine 2,3 dioxygenase (IDO). IDO-competent DCs are a subset of plasmacytoid DCs that can be induced to express IDO under certain inflammatory conditions in humans and mice. Though rare, IDO-expressing DCs acquire potent T cell suppressor activity that may predominate over the T cell stimulatory functions of all other antigen-presenting cells in physiologic environments due in part, to cooperation with regulatory T cells. Thus, IDO-expressing DCs are critical regulators of adaptive immunity that contribute to a wide range of inflammatory disease processes. As such, manipulating IDO expression in DCs using IDO inhibitors or IDO inducers offers considerable opportunities to improve immunotherapies in a range of clinically-significant disease syndromes.

AB - Mature dendritic cells (DCs) are potent stimulators of T cells that recognize antigens presented by the DCs. In this chapter we describe mature DCs that suppress T cell responses to antigens they present due to expression of the intracel-lular enzyme indoleamine 2,3 dioxygenase (IDO). IDO-competent DCs are a subset of plasmacytoid DCs that can be induced to express IDO under certain inflammatory conditions in humans and mice. Though rare, IDO-expressing DCs acquire potent T cell suppressor activity that may predominate over the T cell stimulatory functions of all other antigen-presenting cells in physiologic environments due in part, to cooperation with regulatory T cells. Thus, IDO-expressing DCs are critical regulators of adaptive immunity that contribute to a wide range of inflammatory disease processes. As such, manipulating IDO expression in DCs using IDO inhibitors or IDO inducers offers considerable opportunities to improve immunotherapies in a range of clinically-significant disease syndromes.

UR - http://www.scopus.com/inward/record.url?scp=60549086844&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60549086844&partnerID=8YFLogxK

U2 - 10.1007/978-3-540-71029-5-8

DO - 10.1007/978-3-540-71029-5-8

M3 - Article

C2 - 19031026

AN - SCOPUS:60549086844

VL - 188

SP - 165

EP - 196

JO - Handbook of Experimental Pharmacology

JF - Handbook of Experimental Pharmacology

SN - 0171-2004

ER -