T cells can be activated by peptides that are unrelated in sequence to their selecting peptide

Leszek Ignatowicz, William Rees, Rafal Pacholczyk, Hanna Ignatowicz, Elenora Kushnir, John Kappler, Philippa Marrack

Research output: Contribution to journalArticle

105 Scopus citations

Abstract

We tested the ability of CD4+ T cells, selected in the thymus by reaction with class II protein bound to a single peptide, to react with the same class II protein bound to other peptides. The T cells reacted with all peptides tested, including one that was quite unlike the selecting peptide in T cell receptor binding residues. The receptors on class II/peptide- reactive T cells from class II/single peptide mice were similar but not identical to some of those from normal animals. Thus, class II bound to a single peptide selects a sub-set of T cells that is related to that selected by class II bound to many peptides.

Original languageEnglish (US)
Pages (from-to)179-186
Number of pages8
JournalImmunity
Volume7
Issue number2
DOIs
StatePublished - Aug 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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    Ignatowicz, L., Rees, W., Pacholczyk, R., Ignatowicz, H., Kushnir, E., Kappler, J., & Marrack, P. (1997). T cells can be activated by peptides that are unrelated in sequence to their selecting peptide. Immunity, 7(2), 179-186. https://doi.org/10.1016/S1074-7613(00)80521-X