T cells can be activated by peptides that are unrelated in sequence to their selecting peptide

Leszek Ignatowicz, William Rees, Rafal W Pacholczyk, Hanna Ignatowicz, Elenora Kushnir, John Kappler, Philippa Marrack

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

We tested the ability of CD4+ T cells, selected in the thymus by reaction with class II protein bound to a single peptide, to react with the same class II protein bound to other peptides. The T cells reacted with all peptides tested, including one that was quite unlike the selecting peptide in T cell receptor binding residues. The receptors on class II/peptide- reactive T cells from class II/single peptide mice were similar but not identical to some of those from normal animals. Thus, class II bound to a single peptide selects a sub-set of T cells that is related to that selected by class II bound to many peptides.

Original languageEnglish (US)
Pages (from-to)179-186
Number of pages8
JournalImmunity
Volume7
Issue number2
DOIs
StatePublished - Jan 1 1997

Fingerprint

T-Lymphocytes
Peptides
Peptide T
T-Cell Antigen Receptor
Thymus Gland
Proteins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

T cells can be activated by peptides that are unrelated in sequence to their selecting peptide. / Ignatowicz, Leszek; Rees, William; Pacholczyk, Rafal W; Ignatowicz, Hanna; Kushnir, Elenora; Kappler, John; Marrack, Philippa.

In: Immunity, Vol. 7, No. 2, 01.01.1997, p. 179-186.

Research output: Contribution to journalArticle

Ignatowicz, L, Rees, W, Pacholczyk, RW, Ignatowicz, H, Kushnir, E, Kappler, J & Marrack, P 1997, 'T cells can be activated by peptides that are unrelated in sequence to their selecting peptide', Immunity, vol. 7, no. 2, pp. 179-186. https://doi.org/10.1016/S1074-7613(00)80521-X
Ignatowicz, Leszek ; Rees, William ; Pacholczyk, Rafal W ; Ignatowicz, Hanna ; Kushnir, Elenora ; Kappler, John ; Marrack, Philippa. / T cells can be activated by peptides that are unrelated in sequence to their selecting peptide. In: Immunity. 1997 ; Vol. 7, No. 2. pp. 179-186.
@article{5806885d6e844fbf8afaacbe46b07884,
title = "T cells can be activated by peptides that are unrelated in sequence to their selecting peptide",
abstract = "We tested the ability of CD4+ T cells, selected in the thymus by reaction with class II protein bound to a single peptide, to react with the same class II protein bound to other peptides. The T cells reacted with all peptides tested, including one that was quite unlike the selecting peptide in T cell receptor binding residues. The receptors on class II/peptide- reactive T cells from class II/single peptide mice were similar but not identical to some of those from normal animals. Thus, class II bound to a single peptide selects a sub-set of T cells that is related to that selected by class II bound to many peptides.",
author = "Leszek Ignatowicz and William Rees and Pacholczyk, {Rafal W} and Hanna Ignatowicz and Elenora Kushnir and John Kappler and Philippa Marrack",
year = "1997",
month = "1",
day = "1",
doi = "10.1016/S1074-7613(00)80521-X",
language = "English (US)",
volume = "7",
pages = "179--186",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "2",

}

TY - JOUR

T1 - T cells can be activated by peptides that are unrelated in sequence to their selecting peptide

AU - Ignatowicz, Leszek

AU - Rees, William

AU - Pacholczyk, Rafal W

AU - Ignatowicz, Hanna

AU - Kushnir, Elenora

AU - Kappler, John

AU - Marrack, Philippa

PY - 1997/1/1

Y1 - 1997/1/1

N2 - We tested the ability of CD4+ T cells, selected in the thymus by reaction with class II protein bound to a single peptide, to react with the same class II protein bound to other peptides. The T cells reacted with all peptides tested, including one that was quite unlike the selecting peptide in T cell receptor binding residues. The receptors on class II/peptide- reactive T cells from class II/single peptide mice were similar but not identical to some of those from normal animals. Thus, class II bound to a single peptide selects a sub-set of T cells that is related to that selected by class II bound to many peptides.

AB - We tested the ability of CD4+ T cells, selected in the thymus by reaction with class II protein bound to a single peptide, to react with the same class II protein bound to other peptides. The T cells reacted with all peptides tested, including one that was quite unlike the selecting peptide in T cell receptor binding residues. The receptors on class II/peptide- reactive T cells from class II/single peptide mice were similar but not identical to some of those from normal animals. Thus, class II bound to a single peptide selects a sub-set of T cells that is related to that selected by class II bound to many peptides.

UR - http://www.scopus.com/inward/record.url?scp=0030865858&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030865858&partnerID=8YFLogxK

U2 - 10.1016/S1074-7613(00)80521-X

DO - 10.1016/S1074-7613(00)80521-X

M3 - Article

C2 - 9285403

AN - SCOPUS:0030865858

VL - 7

SP - 179

EP - 186

JO - Immunity

JF - Immunity

SN - 1074-7613

IS - 2

ER -