T cells can be activated by peptides that are unrelated in sequence to their selecting peptide

Leszek Ignatowicz, William Rees, Rafal W Pacholczyk, Hanna Ignatowicz, Elenora Kushnir, John Kappler, Philippa Marrack

Research output: Contribution to journalArticle

104 Scopus citations


We tested the ability of CD4+ T cells, selected in the thymus by reaction with class II protein bound to a single peptide, to react with the same class II protein bound to other peptides. The T cells reacted with all peptides tested, including one that was quite unlike the selecting peptide in T cell receptor binding residues. The receptors on class II/peptide- reactive T cells from class II/single peptide mice were similar but not identical to some of those from normal animals. Thus, class II bound to a single peptide selects a sub-set of T cells that is related to that selected by class II bound to many peptides.

Original languageEnglish (US)
Pages (from-to)179-186
Number of pages8
Issue number2
StatePublished - Jan 1 1997


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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