T594M mutation of the β-subunit of the epithelial sodium channel in Ghanaian populations from Kumasi and London and a possible association with hypertension

Yanbin Dong, J. Plange-Rhule, I. Owusu, F. Micah, J. B. Eastwood, N. D. Carter, A. K. Saggar-Malik, F. P. Cappuccio, S. Jeffery

Research output: Contribution to journalArticle

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Abstract

We have tested 186 individuals from Ghana, 95 indigenous and 91 who have settled in the United Kingdom, for the presence of the T594M mutation in the β-subunit of the epithelial sodium channel, which is associated with hypertension in black populations. The group living in Ghana had a mean age of 27 years and were normotensive, but had an increased frequency of the T allele compared to the London-based population. If this is reflected in larger studies, and the link with hypertension is maintained in the Ghanaian population, this mutation could be a significant cause of hypertension in Ghana.

Original languageEnglish (US)
Pages (from-to)63-65
Number of pages3
JournalGenetic Testing
Volume6
Issue number1
DOIs
StatePublished - Jun 22 2002
Externally publishedYes

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Epithelial Sodium Channels
Ghana
Hypertension
Mutation
Population
Gene Frequency

ASJC Scopus subject areas

  • Genetics(clinical)

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T594M mutation of the β-subunit of the epithelial sodium channel in Ghanaian populations from Kumasi and London and a possible association with hypertension. / Dong, Yanbin; Plange-Rhule, J.; Owusu, I.; Micah, F.; Eastwood, J. B.; Carter, N. D.; Saggar-Malik, A. K.; Cappuccio, F. P.; Jeffery, S.

In: Genetic Testing, Vol. 6, No. 1, 22.06.2002, p. 63-65.

Research output: Contribution to journalArticle

Dong, Y, Plange-Rhule, J, Owusu, I, Micah, F, Eastwood, JB, Carter, ND, Saggar-Malik, AK, Cappuccio, FP & Jeffery, S 2002, 'T594M mutation of the β-subunit of the epithelial sodium channel in Ghanaian populations from Kumasi and London and a possible association with hypertension', Genetic Testing, vol. 6, no. 1, pp. 63-65. https://doi.org/10.1089/109065702760093942
Dong, Yanbin ; Plange-Rhule, J. ; Owusu, I. ; Micah, F. ; Eastwood, J. B. ; Carter, N. D. ; Saggar-Malik, A. K. ; Cappuccio, F. P. ; Jeffery, S. / T594M mutation of the β-subunit of the epithelial sodium channel in Ghanaian populations from Kumasi and London and a possible association with hypertension. In: Genetic Testing. 2002 ; Vol. 6, No. 1. pp. 63-65.
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