Takotsubo cardiomyopathy: A comprehensive review

Walker Barmore, Himax Patel, Sean Harrell, Daniel Garcia, Joe B. Calkins

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Takotsubo cardiomyopathy (TCM), also known as stress cardiomyopathy, occurs in the setting of catecholamine surge from an acute stressor. This cardiomyopathy mimics acute myocardial infarction in the absence of coronary disease. The classic feature of TCM is regional wall motion abnormalities with characteristic ballooning of the left ventricle. The etiology of the stressor is often physical or emotional stress, however iatrogenic causes of TCM have been reported in the literature. In our review, we discuss medications, primarily the exogenous administration of catecholamines, and a wide array of procedures with subsequent development of iatrogenic cardiomyopathy. TCM is unique in that it is transient and has favorable outcomes in most individuals. Classically, beta-blockers and ACE-inhibitors have been prescribed in individuals with cardiomyopathy; however, unique to TCM, no specific treatment is required other than temporary supportive measures as this process is transient. Additionally, no improvement in mortality or recurrence have been reported in patients on these drugs. The aim of this review is to elucidate on the iatrogenic causes of TCM, allowing for prompt recognition and management by clinicians.

Original languageEnglish (US)
Pages (from-to)355-362
Number of pages8
JournalWorld Journal of Cardiology
Issue number6
StatePublished - Jun 1 2022
Externally publishedYes


  • Cardiomyopathy
  • Heart Failure
  • Iatrogenic
  • Myocardial Infarction
  • Takotsubo

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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