Targeting neovascularization in ischemic retinopathy: Recent advances

Mohamed Al-Shabrawey, Mohamed Elsherbiny, Julian J Nussbaum, Amira Othman, Sylvia Megyerdi, Amany Mohamed Tawfik

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Pathological retinal neovascularization (RNV) is a common microvascular complication in several retinal diseases including retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration and central vein occlusion. The current therapeutic modalities of RNV are invasive and although they may slow or halt the progression of the disease, they are unlikely to restore normal acuity. Therefore, there is an urgent need to develop treatment modalities that are less invasive and thus associated with fewer procedural complications and systemic side effects. This review article summarizes our understanding of the pathophysiology and current treatment of RNV in ischemic retinopathies, lists potential therapeutic targets and provides a framework for the development of future treatment modalities.

Original languageEnglish (US)
Pages (from-to)267-286
Number of pages20
JournalExpert Review of Ophthalmology
Volume8
Issue number3
DOIs
StatePublished - Jun 1 2013

Fingerprint

Retinal Neovascularization
Pathologic Neovascularization
Retinal Diseases
Retinopathy of Prematurity
Macular Degeneration
Diabetic Retinopathy
Disease Progression
Veins
Therapeutics

Keywords

  • PEDF
  • PPAR
  • VEGF
  • inflammation
  • lipoxygenase
  • oxidative stress
  • retinal neovascularization
  • retinopathy

ASJC Scopus subject areas

  • Biomedical Engineering
  • Ophthalmology
  • Optometry

Cite this

Targeting neovascularization in ischemic retinopathy : Recent advances. / Al-Shabrawey, Mohamed; Elsherbiny, Mohamed; Nussbaum, Julian J; Othman, Amira; Megyerdi, Sylvia; Tawfik, Amany Mohamed.

In: Expert Review of Ophthalmology, Vol. 8, No. 3, 01.06.2013, p. 267-286.

Research output: Contribution to journalReview article

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