Targeting ROS-Mediated Crosstalk Between Autophagy and Apoptosis in Cancer

Lixia Gao, Jenni Loveless, Chloe Shay, Yong Teng

Research output: Contribution to journalArticle


The control of crosstalk between autophagy and apoptosis in tumor cells can remove a critical barrier to comprehensive and efficacious treatment for cancer. Reactive oxygen species (ROS), by-products of redox homeostasis, are critical for regulating the balance between autophagy and apoptosis in cancer cells upon different drug treatments and gene modifications. The mechanisms and consequences involved in ROS-mediated crosstalk between apoptosis and autophagy are extremely complex in cancer cells. Here, we mainly discuss the closely linked relationship between ROS levels, autophagy, and apoptosis in cancer therapy.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalAdvances in experimental medicine and biology
StatePublished - Jan 1 2020


  • Anticancer strategy
  • Apoptosis
  • Autophagy
  • Cancer
  • Reactive oxygen species
  • ROS

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Targeting ROS-Mediated Crosstalk Between Autophagy and Apoptosis in Cancer'. Together they form a unique fingerprint.

  • Cite this