Targeting ros-mediated crosstalk between autophagy and apoptosis in cancer

Lixia Gao, Jenni Loveless, Chloe Shay, Yong Teng

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The control of crosstalk between autophagy and apoptosis in tumor cells can remove a critical barrier to comprehensive and efficacious treatment for cancer. Reactive oxygen species (ROS), by-products of redox homeostasis, are critical for regulating the balance between autophagy and apoptosis in cancer cells upon different drug treatments and gene modifications. The mechanisms and consequences involved in ROS-mediated crosstalk between apoptosis and autophagy are extremely complex in cancer cells. Here, we mainly discuss the closely linked relationship between ROS levels, autophagy, and apoptosis in cancer therapy.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages1-12
Number of pages12
DOIs
StatePublished - 2020

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1260
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Anticancer strategy
  • Apoptosis
  • Autophagy
  • Cancer
  • ROS
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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