Targeting sources of superoxide and increasing nitric oxide bioavailability in hypertension

Ahmed Abdelrazik Elmarakby, Jan Michael Williams, David M. Pollock

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Overproduction of oxygen free radicals, which is mainly mediated by superoxide, occurs in human hypertension and a wide variety of animal models. There are several important enzymatic sources of superoxide production, including NADPH oxidase, xanthine oxidase and uncoupled nitric oxide synthase. Superoxide levels are also controlled through endogenous antioxidant systems and superoxide dismutase is the primary antioxidant in the vascular system. Strategies have therefore focused on combating hypertension and vascular disease through the inhibition of superoxide-generating enzymes, and scavenging superoxide. While results from animal studies are promising, no consensus has been reached on identifying a drug target for the reliable and effective treatment ofoxidative stress in hypertension.

Original languageEnglish (US)
Pages (from-to)282-290
Number of pages9
JournalCurrent Opinion in Investigational Drugs
Volume4
Issue number3
StatePublished - Mar 1 2003

Fingerprint

Superoxides
Biological Availability
Nitric Oxide
Hypertension
Antioxidants
Xanthine Oxidase
NADPH Oxidase
Vascular Diseases
Nitric Oxide Synthase
Superoxide Dismutase
Free Radicals
Blood Vessels
Reactive Oxygen Species
Animal Models
Enzymes
Pharmaceutical Preparations

Keywords

  • Allopurinol
  • Apocynin
  • Nitric oxide
  • Oxidative stress
  • Superoxide
  • Tempol
  • Vitamiin C
  • Vitamin E

ASJC Scopus subject areas

  • Pharmacology

Cite this

Targeting sources of superoxide and increasing nitric oxide bioavailability in hypertension. / Elmarakby, Ahmed Abdelrazik; Williams, Jan Michael; Pollock, David M.

In: Current Opinion in Investigational Drugs, Vol. 4, No. 3, 01.03.2003, p. 282-290.

Research output: Contribution to journalReview article

@article{b5e74347a90d48b39b010890c399673c,
title = "Targeting sources of superoxide and increasing nitric oxide bioavailability in hypertension",
abstract = "Overproduction of oxygen free radicals, which is mainly mediated by superoxide, occurs in human hypertension and a wide variety of animal models. There are several important enzymatic sources of superoxide production, including NADPH oxidase, xanthine oxidase and uncoupled nitric oxide synthase. Superoxide levels are also controlled through endogenous antioxidant systems and superoxide dismutase is the primary antioxidant in the vascular system. Strategies have therefore focused on combating hypertension and vascular disease through the inhibition of superoxide-generating enzymes, and scavenging superoxide. While results from animal studies are promising, no consensus has been reached on identifying a drug target for the reliable and effective treatment ofoxidative stress in hypertension.",
keywords = "Allopurinol, Apocynin, Nitric oxide, Oxidative stress, Superoxide, Tempol, Vitamiin C, Vitamin E",
author = "Elmarakby, {Ahmed Abdelrazik} and Williams, {Jan Michael} and Pollock, {David M.}",
year = "2003",
month = "3",
day = "1",
language = "English (US)",
volume = "4",
pages = "282--290",
journal = "Expert Opinion on Investigational Drugs",
issn = "1354-3784",
publisher = "Taylor and Francis Ltd.",
number = "3",

}

TY - JOUR

T1 - Targeting sources of superoxide and increasing nitric oxide bioavailability in hypertension

AU - Elmarakby, Ahmed Abdelrazik

AU - Williams, Jan Michael

AU - Pollock, David M.

PY - 2003/3/1

Y1 - 2003/3/1

N2 - Overproduction of oxygen free radicals, which is mainly mediated by superoxide, occurs in human hypertension and a wide variety of animal models. There are several important enzymatic sources of superoxide production, including NADPH oxidase, xanthine oxidase and uncoupled nitric oxide synthase. Superoxide levels are also controlled through endogenous antioxidant systems and superoxide dismutase is the primary antioxidant in the vascular system. Strategies have therefore focused on combating hypertension and vascular disease through the inhibition of superoxide-generating enzymes, and scavenging superoxide. While results from animal studies are promising, no consensus has been reached on identifying a drug target for the reliable and effective treatment ofoxidative stress in hypertension.

AB - Overproduction of oxygen free radicals, which is mainly mediated by superoxide, occurs in human hypertension and a wide variety of animal models. There are several important enzymatic sources of superoxide production, including NADPH oxidase, xanthine oxidase and uncoupled nitric oxide synthase. Superoxide levels are also controlled through endogenous antioxidant systems and superoxide dismutase is the primary antioxidant in the vascular system. Strategies have therefore focused on combating hypertension and vascular disease through the inhibition of superoxide-generating enzymes, and scavenging superoxide. While results from animal studies are promising, no consensus has been reached on identifying a drug target for the reliable and effective treatment ofoxidative stress in hypertension.

KW - Allopurinol

KW - Apocynin

KW - Nitric oxide

KW - Oxidative stress

KW - Superoxide

KW - Tempol

KW - Vitamiin C

KW - Vitamin E

UR - http://www.scopus.com/inward/record.url?scp=0038078489&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038078489&partnerID=8YFLogxK

M3 - Review article

VL - 4

SP - 282

EP - 290

JO - Expert Opinion on Investigational Drugs

JF - Expert Opinion on Investigational Drugs

SN - 1354-3784

IS - 3

ER -