Abstract
Overproduction of oxygen free radicals, which is mainly mediated by superoxide, occurs in human hypertension and a wide variety of animal models. There are several important enzymatic sources of superoxide production, including NADPH oxidase, xanthine oxidase and uncoupled nitric oxide synthase. Superoxide levels are also controlled through endogenous antioxidant systems and superoxide dismutase is the primary antioxidant in the vascular system. Strategies have therefore focused on combating hypertension and vascular disease through the inhibition of superoxide-generating enzymes, and scavenging superoxide. While results from animal studies are promising, no consensus has been reached on identifying a drug target for the reliable and effective treatment ofoxidative stress in hypertension.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 282-290 |
| Number of pages | 9 |
| Journal | Current Opinion in Investigational Drugs |
| Volume | 4 |
| Issue number | 3 |
| State | Published - Mar 1 2003 |
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Keywords
- Allopurinol
- Apocynin
- Nitric oxide
- Oxidative stress
- Superoxide
- Tempol
- Vitamiin C
- Vitamin E
ASJC Scopus subject areas
- Pharmacology
Cite this
Targeting sources of superoxide and increasing nitric oxide bioavailability in hypertension. / Elmarakby, Ahmed Abdelrazik; Williams, Jan Michael; Pollock, David M.
In: Current Opinion in Investigational Drugs, Vol. 4, No. 3, 01.03.2003, p. 282-290.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Targeting sources of superoxide and increasing nitric oxide bioavailability in hypertension
AU - Elmarakby, Ahmed Abdelrazik
AU - Williams, Jan Michael
AU - Pollock, David M.
PY - 2003/3/1
Y1 - 2003/3/1
N2 - Overproduction of oxygen free radicals, which is mainly mediated by superoxide, occurs in human hypertension and a wide variety of animal models. There are several important enzymatic sources of superoxide production, including NADPH oxidase, xanthine oxidase and uncoupled nitric oxide synthase. Superoxide levels are also controlled through endogenous antioxidant systems and superoxide dismutase is the primary antioxidant in the vascular system. Strategies have therefore focused on combating hypertension and vascular disease through the inhibition of superoxide-generating enzymes, and scavenging superoxide. While results from animal studies are promising, no consensus has been reached on identifying a drug target for the reliable and effective treatment ofoxidative stress in hypertension.
AB - Overproduction of oxygen free radicals, which is mainly mediated by superoxide, occurs in human hypertension and a wide variety of animal models. There are several important enzymatic sources of superoxide production, including NADPH oxidase, xanthine oxidase and uncoupled nitric oxide synthase. Superoxide levels are also controlled through endogenous antioxidant systems and superoxide dismutase is the primary antioxidant in the vascular system. Strategies have therefore focused on combating hypertension and vascular disease through the inhibition of superoxide-generating enzymes, and scavenging superoxide. While results from animal studies are promising, no consensus has been reached on identifying a drug target for the reliable and effective treatment ofoxidative stress in hypertension.
KW - Allopurinol
KW - Apocynin
KW - Nitric oxide
KW - Oxidative stress
KW - Superoxide
KW - Tempol
KW - Vitamiin C
KW - Vitamin E
UR - http://www.scopus.com/inward/record.url?scp=0038078489&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038078489&partnerID=8YFLogxK
M3 - Review article
C2 - 12735229
AN - SCOPUS:0038078489
VL - 4
SP - 282
EP - 290
JO - Expert Opinion on Investigational Drugs
JF - Expert Opinion on Investigational Drugs
SN - 1354-3784
IS - 3
ER -