Targeting the vascular RhoA-Rho-kinase signaling pathway in hypertension

Cleber E. Teixeira, R Clinton Webb

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Considerable evidence demonstrates that RhoA-Rho-kinase signaling plays an important role in various cellular functions including vascular smooth muscle contraction. Animal experiments have demonstrated a prominent role for this signaling cascade in different models of hypertension. This review describes the physiological and pathophysiological roles of the RhoA-Rho-kinase pathway, that can be considered as novel therapeutic targets in the treatment of cardiovascular diseases, such as hypertension.

Original languageEnglish (US)
Pages (from-to)193-199
Number of pages7
JournalDrug Discovery Today: Therapeutic Strategies
Volume2
Issue number3
DOIs
StatePublished - Oct 31 2005

Fingerprint

rho-Associated Kinases
Blood Vessels
Hypertension
Muscle Contraction
Vascular Smooth Muscle
Cardiovascular Diseases
Therapeutics

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

Cite this

Targeting the vascular RhoA-Rho-kinase signaling pathway in hypertension. / Teixeira, Cleber E.; Webb, R Clinton.

In: Drug Discovery Today: Therapeutic Strategies, Vol. 2, No. 3, 31.10.2005, p. 193-199.

Research output: Contribution to journalReview article

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