Targeting the vascular RhoA-Rho-kinase signaling pathway in hypertension

Cleber E. Teixeira, R Clinton Webb

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Considerable evidence demonstrates that RhoA-Rho-kinase signaling plays an important role in various cellular functions including vascular smooth muscle contraction. Animal experiments have demonstrated a prominent role for this signaling cascade in different models of hypertension. This review describes the physiological and pathophysiological roles of the RhoA-Rho-kinase pathway, that can be considered as novel therapeutic targets in the treatment of cardiovascular diseases, such as hypertension.

Original languageEnglish (US)
Pages (from-to)193-199
Number of pages7
JournalDrug Discovery Today: Therapeutic Strategies
Volume2
Issue number3
DOIs
Publication statusPublished - Oct 31 2005

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