Abstract
Considerable evidence demonstrates that RhoA-Rho-kinase signaling plays an important role in various cellular functions including vascular smooth muscle contraction. Animal experiments have demonstrated a prominent role for this signaling cascade in different models of hypertension. This review describes the physiological and pathophysiological roles of the RhoA-Rho-kinase pathway, that can be considered as novel therapeutic targets in the treatment of cardiovascular diseases, such as hypertension.
Original language | English (US) |
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Pages (from-to) | 193-199 |
Number of pages | 7 |
Journal | Drug Discovery Today: Therapeutic Strategies |
Volume | 2 |
Issue number | 3 |
DOIs | |
State | Published - 2005 |
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
- Drug Discovery