Targeting tumor microenvironment-associated cells to reverse therapy resistance

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

About 30%-70% of the cells in any tumor are composed of noncancerous cells [1,2], with the most abundant cells in GBM coming from bone marrow-derived cells [3,4]. Although the presence of cancer-associated fibroblasts in the GBM environment is controversial, there are plentiful microglia [5-8]. Microglia are known to contribute to the immunosuppressive environment of gliomas. In this chapter, the influence of different GBM TME-associated cells (such as bone marrow derived cells) will be discussed concerning the possible cause of therapy resistance. The discussion will also involve possible ways to prevent therapy resistance due to TME-associated cells.

Original languageEnglish (US)
Title of host publicationNew Targeting in the Reversal of Resistant Glioblastomas
PublisherElsevier
Pages115-144
Number of pages30
ISBN (Electronic)9780128225271
ISBN (Print)9780128232767
DOIs
StatePublished - Jan 1 2021

Keywords

  • Bone marrow-derived cells
  • Macrophages
  • MDSC
  • Microglia
  • Myeloid cells
  • Platelets
  • T cells
  • Tumor microenvironment

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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