Targeting tumor microenvironment-associated cells to reverse therapy resistance

Raziye Piranlioglu; Jennifer W. Bradford; Ali Syed Arbab

doi:10.1016/B978-0-12-822527-1.00006-X

Targeting tumor microenvironment-associated cells to reverse therapy resistance

Raziye Piranlioglu, Jennifer W. Bradford, Ali Syed Arbab

Biological Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

About 30%-70% of the cells in any tumor are composed of noncancerous cells [1,2], with the most abundant cells in GBM coming from bone marrow-derived cells [3,4]. Although the presence of cancer-associated fibroblasts in the GBM environment is controversial, there are plentiful microglia [5-8]. Microglia are known to contribute to the immunosuppressive environment of gliomas. In this chapter, the influence of different GBM TME-associated cells (such as bone marrow derived cells) will be discussed concerning the possible cause of therapy resistance. The discussion will also involve possible ways to prevent therapy resistance due to TME-associated cells.

Original language	English (US)
Title of host publication	New Targeting in the Reversal of Resistant Glioblastomas
Publisher	Elsevier
Pages	115-144
Number of pages	30
ISBN (Electronic)	9780128225271
ISBN (Print)	9780128232767
DOIs	https://doi.org/10.1016/B978-0-12-822527-1.00006-X
State	Published - Jan 1 2021

Keywords

Bone marrow-derived cells
MDSC
Macrophages
Microglia
Myeloid cells
Platelets
T cells
Tumor microenvironment

ASJC Scopus subject areas

General Agricultural and Biological Sciences
General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/B978-0-12-822527-1.00006-X

Cite this

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AU - Bradford, Jennifer W.

AU - Arbab, Ali Syed

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AB - About 30%-70% of the cells in any tumor are composed of noncancerous cells [1,2], with the most abundant cells in GBM coming from bone marrow-derived cells [3,4]. Although the presence of cancer-associated fibroblasts in the GBM environment is controversial, there are plentiful microglia [5-8]. Microglia are known to contribute to the immunosuppressive environment of gliomas. In this chapter, the influence of different GBM TME-associated cells (such as bone marrow derived cells) will be discussed concerning the possible cause of therapy resistance. The discussion will also involve possible ways to prevent therapy resistance due to TME-associated cells.

KW - Bone marrow-derived cells

KW - MDSC

KW - Macrophages

KW - Microglia

KW - Myeloid cells

KW - Platelets

KW - T cells

KW - Tumor microenvironment

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BT - New Targeting in the Reversal of Resistant Glioblastomas

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ER -

Targeting tumor microenvironment-associated cells to reverse therapy resistance

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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