Targeting WASF3 signaling in metastatic cancer

Reid Loveless, Yong Teng

Research output: Contribution to journalArticlepeer-review

Abstract

Increasing evidence indicates that cancer metastasis is regulated by specific genetic pathways independent of those controlling tumorigenesis and cancer growth. WASF3, a Wiskott-Aldrich syndrome protein family member, appears to play a major role not only in the regulation of actin cytoskeleton dynamics but also in cancer cell invasion/metastasis. Recent studies have highlighted that WASF3 is a master regulator and acts as a pivotal scaffolding protein, bringing the various components of metastatic signaling complexes together both spatially and temporally. Herein, targeting WASF3 at the levels of transcription, protein stability, and phosphorylation holds great promise for metastasis suppression, regardless of the diverse genetic backgrounds associated with tumor development. This review focuses on the critical and distinct contributions of WASF3 in the regulation of signal pathways promoting cancer cell invasion and metastasis.

Original languageEnglish (US)
Article number836
Pages (from-to)1-14
Number of pages14
JournalInternational journal of molecular sciences
Volume22
Issue number2
DOIs
StatePublished - Jan 2 2021

Keywords

  • Cancer
  • Drug target
  • Metastasis
  • Signaling network
  • WASF3

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Fingerprint Dive into the research topics of 'Targeting WASF3 signaling in metastatic cancer'. Together they form a unique fingerprint.

Cite this