Taurine ameliorates neurobehavioral, neurochemical and immunohistochemical changes in sporadic dementia of Alzheimer's type (SDAT) caused by intracerebroventricular streptozotocin in rats

Fakhrul Islam, Hayate Javed, Andleeb Khan, Kumar Vaibhav, Mohd Moshahid Khan, Ajmal Ahmad, Md Ejaz Ahmad, Ashafaq Ahmad, Rizwana Tabassum, Farah Islam, Mohammed M. Safhi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Oxidative loads in the brain are involved in age related impairments like learning and memory as well as neurodegeneration. Taurine, the most abundant free amino acid in humans has many potential health benefits through its anti-oxidant and anti-inflammatory properties. Therefore, we investigated the neuroprotective potential of taurine on oxidative stress, neuronal loss and memory impairments in streptozotocin model of cognitive impairments in rats. The cognitive impairment was developed by giving single intracerebroventricular (ICV) injection of streptozotocin (STZ) 3 mg/kg body weight bilaterally. An increased latency and path length was observed in ICV-STZ group animals as compared to sham group animals and these were inhibited significantly in STZ group pre-treated with taurine (50 mg/kg body weight orally once daily for 15 days). Moreover, the significantly depleted content of GSH and elevated level of thiobarbituric acid reactive substances (TBARS) in ICV-STZ group animals were protected significantly with pre-treatment of taurine. The activity of antioxidant enzymes, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, catalase, and superoxide dismutase was decreased in STZ group as compared to sham group and pre-treatment of STZ group with taurine has protected their activities significantly. Furthermore, the increased activity of acetylcholine esterase and decreased expression of choline acetyl transferase were attenuated by the pre-treatment of taurine. Taurine also protected the morphology of the hippocampal pyramidal neurons. This study concludes that the prophylactic intervention of taurine may be used to prevent the deterioration of cognitive functions and neurobehavioral activities, often associated with the generation of free radicals.

Original languageEnglish (US)
Pages (from-to)2181-2192
Number of pages12
JournalNeurological Sciences
Volume34
Issue number12
DOIs
StatePublished - Dec 1 2013
Externally publishedYes

Fingerprint

Taurine
Streptozocin
Alzheimer Disease
Body Weight
Thiobarbituric Acid Reactive Substances
Glutathione Reductase
Pyramidal Cells
Memory Disorders
Insurance Benefits
Esterases
Glutathione Peroxidase
Transferases
Choline
Glutathione Transferase
Oxidants
Catalase
Cognition
Acetylcholine
Superoxide Dismutase
Free Radicals

Keywords

  • Antioxidants
  • Cognitive impairments
  • Oxidative stress
  • Streptozotocin
  • Taurine

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Taurine ameliorates neurobehavioral, neurochemical and immunohistochemical changes in sporadic dementia of Alzheimer's type (SDAT) caused by intracerebroventricular streptozotocin in rats. / Islam, Fakhrul; Javed, Hayate; Khan, Andleeb; Vaibhav, Kumar; Moshahid Khan, Mohd; Ahmad, Ajmal; Ejaz Ahmad, Md; Ahmad, Ashafaq; Tabassum, Rizwana; Islam, Farah; Safhi, Mohammed M.

In: Neurological Sciences, Vol. 34, No. 12, 01.12.2013, p. 2181-2192.

Research output: Contribution to journalArticle

Islam, Fakhrul ; Javed, Hayate ; Khan, Andleeb ; Vaibhav, Kumar ; Moshahid Khan, Mohd ; Ahmad, Ajmal ; Ejaz Ahmad, Md ; Ahmad, Ashafaq ; Tabassum, Rizwana ; Islam, Farah ; Safhi, Mohammed M. / Taurine ameliorates neurobehavioral, neurochemical and immunohistochemical changes in sporadic dementia of Alzheimer's type (SDAT) caused by intracerebroventricular streptozotocin in rats. In: Neurological Sciences. 2013 ; Vol. 34, No. 12. pp. 2181-2192.
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AU - Moshahid Khan, Mohd

AU - Ahmad, Ajmal

AU - Ejaz Ahmad, Md

AU - Ahmad, Ashafaq

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AU - Islam, Farah

AU - Safhi, Mohammed M.

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