Taurine depletion alters vascular reactivity in rats

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We recently showed that chronic taurine supplementation is associated with attenuation of contractile responses of rat aorta to norepinephrine and potassium chloride. However, the potential involvement of endogenous taurine in modulation of vascular reactivity is not known. Therefore, we examined the effect of β-alanine-induced taurine depletion on the in vitro reactivity of rat aorta to selected vasoactive agents. The data indicate that both norepinephrine- and potassium-chloride-induced maximum contractile responses of endothelium-denuded aortae were enhanced in taurine-depleted rats compared with control animals. However, taurine depletion did not affect tissue sensitivity to either norepinephrine or potassium chloride. By contrast, sensitivity of the endothelium-denuded aortae to sodium nitroprusside was attenuated by taurine depletion. Similarly, taurine deficiency reduced the relaxant responses of endothelium-intact aortic rings elicited by submaximal concentrations of acetylcholine, and this effect was associated with decreased nitric oxide production. Taken together, the data suggest that taurine depletion augments contractility but attenuates relaxation of vascular smooth muscle in a nonspecific manner. Impairment of endothelium-dependent responses, which is at least in part associated with reduced nitric oxide generation, may contribute to the attenuation of the vasorelaxant responses. These vascular alterations could be of potential consequence in pathological conditions associated with taurine deficiency.

Original languageEnglish (US)
Pages (from-to)903-909
Number of pages7
JournalCanadian Journal of Physiology and Pharmacology
Volume81
Issue number9
DOIs
StatePublished - Sep 1 2003

Fingerprint

Taurine
Blood Vessels
Endothelium
Potassium Chloride
Aorta
Norepinephrine
Nitric Oxide
Nitroprusside
Vasodilator Agents
Vascular Smooth Muscle
Alanine
Acetylcholine

Keywords

  • β-alanine
  • Rat aorta
  • Taurine depletion
  • Vascular reactivity

ASJC Scopus subject areas

  • Physiology
  • Pharmacology

Cite this

Taurine depletion alters vascular reactivity in rats. / Abebe, Worku; Mozaffari, Mahmood S.

In: Canadian Journal of Physiology and Pharmacology, Vol. 81, No. 9, 01.09.2003, p. 903-909.

Research output: Contribution to journalArticle

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