Tauroursodeoxycholic acid alleviates secondary injury in the spinal cord via up-regulation of CIBZ gene

Zongmeng Zhang, Jie Chen, Fanghui Chen, Daolun Yu, Rui Li, Chenglong Lv, Haosen Wang, Honglin Li, Jun Li, Yafei Cai

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Spinal cord injury (SCI) is generally divided into primary and secondary injuries, and apoptosis is an important event of the secondary injury. As an endogenous bile acid and recognized endoplasmic reticulum (ER) stress inhibitor, tauroursodeoxycholic acid (TUDCA) administration has been reported to have a potentially therapeutic effect on neurodegenerative diseases, but its real mechanism is still unclear. In this study, we evaluated whether TUDCA could alleviate traumatic damage of the spinal cord and improve locomotion function in a mouse model of SCI. Traumatic SCI mice were intraperitoneally injected with TUDCA, and the effects were evaluated based on motor function assessment, histopathology, apoptosis detection, qRT-PCR, and western blot at different time periods. TUDCA administration can improve motor function and reduce secondary injury and lesion area after SCI. Furthermore, the apoptotic ratios were significantly reduced; Grp78, Erdj4, and CHOP were attenuated by the treatment. Unexpectedly, the levels of CIBZ, a novel therapeutic target for SCI, were specifically up-regulated. Taken together, it is suggested that TUDCA effectively suppressed ER stress through targeted up-regulation of CIBZ. This study also provides a new strategy for relieving secondary damage by inhibiting apoptosis in the early treatment of spinal cord injury.

Original languageEnglish (US)
Pages (from-to)551-560
Number of pages10
JournalCell Stress and Chaperones
Volume23
Issue number4
DOIs
StatePublished - Jul 1 2018

Keywords

  • Apoptosis
  • CIBZ
  • ER stress
  • Spinal cord injury
  • Tauroursodeoxycholic acid

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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