Techniques for physicochemical characterization of nanomaterials

Ping Chang Lin, Stephen Lin, Paul C. Wang, Rajagopalan Sridhar

Research output: Contribution to journalReview article

206 Scopus citations

Abstract

Advances in nanotechnology have opened up a new era of diagnosis, prevention and treatment of diseases and traumatic injuries. Nanomaterials, including those with potential for clinical applications, possess novel physicochemical properties that have an impact on their physiological interactions, from the molecular level to the systemic level. There is a lack of standardized methodologies or regulatory protocols for detection or characterization of nanomaterials. This review summarizes the techniques that are commonly used to study the size, shape, surface properties, composition, purity and stability of nanomaterials, along with their advantages and disadvantages. At present there are no FDA guidelines that have been developed specifically for nanomaterial based formulations for diagnostic or therapeutic use. There is an urgent need for standardized protocols and procedures for the characterization of nanoparticles, especially those that are intended for use as theranostics.

Original languageEnglish (US)
Pages (from-to)711-726
Number of pages16
JournalBiotechnology Advances
Volume32
Issue number4
DOIs
StatePublished - Jul 2014

Keywords

  • Image contrast agents
  • Molecular imaging
  • Nanomedicine
  • Nanoparticle
  • Physicochemical properties

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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