TEDDY - The Environmental Determinants of Diabetes in the Young: An observational clinical trial

William A. Hagopian, Åke Lernmark, Marian J. Rewers, Olli G. Simell, Jin Xiong She, Anette G. Ziegler, Jeffrey P. Krischer, Beena Akolkar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

70 Citations (Scopus)

Abstract

The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (6) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High-risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first-degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and demanding a prospective study.

Original languageEnglish (US)
Title of host publicationImmunology of Diabetes IV
Subtitle of host publicationProgress in Our Understanding
PublisherBlackwell Publishing Inc.
Pages320-326
Number of pages7
ISBN (Print)1573316415, 9781573316415
DOIs
StatePublished - Oct 2006

Publication series

NameAnnals of the New York Academy of Sciences
Volume1079
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Fingerprint

Medical problems
Clinical Trials
Newborn Infant
Type 1 Diabetes Mellitus
Genotype
Autoantibodies
Autoimmunity
Prospective Studies
Psychology
Population
Diabetes
Newborn
Diabetes Mellitus

Keywords

  • HLA
  • Islet autoantibodies
  • Type 1 diabetes
  • Virus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Hagopian, W. A., Lernmark, Å., Rewers, M. J., Simell, O. G., She, J. X., Ziegler, A. G., ... Akolkar, B. (2006). TEDDY - The Environmental Determinants of Diabetes in the Young: An observational clinical trial. In Immunology of Diabetes IV: Progress in Our Understanding (pp. 320-326). (Annals of the New York Academy of Sciences; Vol. 1079). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1375.049

TEDDY - The Environmental Determinants of Diabetes in the Young : An observational clinical trial. / Hagopian, William A.; Lernmark, Åke; Rewers, Marian J.; Simell, Olli G.; She, Jin Xiong; Ziegler, Anette G.; Krischer, Jeffrey P.; Akolkar, Beena.

Immunology of Diabetes IV: Progress in Our Understanding. Blackwell Publishing Inc., 2006. p. 320-326 (Annals of the New York Academy of Sciences; Vol. 1079).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hagopian, WA, Lernmark, Å, Rewers, MJ, Simell, OG, She, JX, Ziegler, AG, Krischer, JP & Akolkar, B 2006, TEDDY - The Environmental Determinants of Diabetes in the Young: An observational clinical trial. in Immunology of Diabetes IV: Progress in Our Understanding. Annals of the New York Academy of Sciences, vol. 1079, Blackwell Publishing Inc., pp. 320-326. https://doi.org/10.1196/annals.1375.049
Hagopian WA, Lernmark Å, Rewers MJ, Simell OG, She JX, Ziegler AG et al. TEDDY - The Environmental Determinants of Diabetes in the Young: An observational clinical trial. In Immunology of Diabetes IV: Progress in Our Understanding. Blackwell Publishing Inc. 2006. p. 320-326. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1375.049
Hagopian, William A. ; Lernmark, Åke ; Rewers, Marian J. ; Simell, Olli G. ; She, Jin Xiong ; Ziegler, Anette G. ; Krischer, Jeffrey P. ; Akolkar, Beena. / TEDDY - The Environmental Determinants of Diabetes in the Young : An observational clinical trial. Immunology of Diabetes IV: Progress in Our Understanding. Blackwell Publishing Inc., 2006. pp. 320-326 (Annals of the New York Academy of Sciences).
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