TY - GEN
T1 - TEDDY - The Environmental Determinants of Diabetes in the Young
T2 - An observational clinical trial
AU - Hagopian, William A.
AU - Lernmark, Åke
AU - Rewers, Marian J.
AU - Simell, Olli G.
AU - She, Jin Xiong
AU - Ziegler, Anette G.
AU - Krischer, Jeffrey P.
AU - Akolkar, Beena
PY - 2006/10
Y1 - 2006/10
N2 - The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (6) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High-risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first-degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and demanding a prospective study.
AB - The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (6) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High-risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first-degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and demanding a prospective study.
KW - HLA
KW - Islet autoantibodies
KW - Type 1 diabetes
KW - Virus
UR - http://www.scopus.com/inward/record.url?scp=33845701367&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845701367&partnerID=8YFLogxK
U2 - 10.1196/annals.1375.049
DO - 10.1196/annals.1375.049
M3 - Conference contribution
C2 - 17130573
AN - SCOPUS:33845701367
SN - 1573316415
SN - 9781573316415
T3 - Annals of the New York Academy of Sciences
SP - 320
EP - 326
BT - Immunology of Diabetes IV
PB - Blackwell Publishing Inc.
ER -