Telechelic Poly(2-oxazoline)s with a biocidal and a polymerizable terminal as collagenase inhibiting additive for long-term active antimicrobial dental materials

Christoph P. Fik, Stefan Konieczny, David H. Pashley, Christian J. Waschinski, Reinhild S. Ladisch, Ulrich Salz, Thorsten Bock, Joerg C. Tiller

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Dental repair materials face the problem that the dentin below the composite fillings is actively decomposed by secondary caries and extracellular proteases. To address this problem, poly(2-methyloxazoline) with a biocidal and a polymerizable terminal was explored as additive for a commercial dental adhesive. 2.5 wt% of the additive rendered the adhesive contact-active against Streptococcus mutans and washing with water for 101 d did not diminish this effect. The adhesive with 5 wt% additive kills S. mutans cells in the tubuli of bovine dentin. Further, the additive inhibits bacterial collagenase at 0.5 wt% and reduces activity of MMP-9. Human MMPs bound to dentin are inhibited by 96% in a medium with 5 wt% additive. Moreover, no adverse effect on the enamel/dentine shear bond strength was detected.

Original languageEnglish (US)
Pages (from-to)1569-1579
Number of pages11
JournalMacromolecular Bioscience
Volume14
Issue number11
DOIs
StatePublished - Nov 1 2014

Keywords

  • antimicrobial
  • collagenase inhibitors
  • dental adhesives
  • notched-edge
  • polyoxazoline
  • self-etch

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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