Telomerase activity in preleukemia and acute myelogenous leukemia

Biaoru Li, Jie Yang, Colleen Andrews, Yi Xin Chen, Paul Toofanfard, Ray Win Huang, Erzsebet Horvath, Harpreet Chopra, Azra Raza, Harvey D. Preisler

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The development of acute leukemia from preleukemia involves the appearance of clones with increasing proliferative potential. The studies described here demonstrate that telomerase activity progressively increases as the bone marrow cells acquire increasing proliferative potential. This was demonstrated by measuring telomerase activity in normal bone marrow, in post-treatment lymphoma marrows with skewed Lyonization, and in MDS and AML marrows. The greater telomerase activity in myelodysplastic marrow than in normal marrow is not due to a higher proportion of blast cells or to a higher proliferative rate of the MDS marrow. These data demonstrate that the increasing proliferative potential of the marrow which occurs during the development of AML is associated with a simultaneous increase in telomerase activity.

Original languageEnglish (US)
Pages (from-to)579-587
Number of pages9
JournalLeukemia and Lymphoma
Volume36
Issue number5-6
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Fingerprint

Preleukemia
Telomerase
Acute Myeloid Leukemia
Bone Marrow
X Chromosome Inactivation
Bone Marrow Cells
Lymphoma
Leukemia
Clone Cells

Keywords

  • Cell proliferation
  • Histone H3
  • Monoclonality
  • Telomerase
  • Telomere

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Li, B., Yang, J., Andrews, C., Chen, Y. X., Toofanfard, P., Huang, R. W., ... Preisler, H. D. (2000). Telomerase activity in preleukemia and acute myelogenous leukemia. Leukemia and Lymphoma, 36(5-6), 579-587. https://doi.org/10.3109/10428190009148406

Telomerase activity in preleukemia and acute myelogenous leukemia. / Li, Biaoru; Yang, Jie; Andrews, Colleen; Chen, Yi Xin; Toofanfard, Paul; Huang, Ray Win; Horvath, Erzsebet; Chopra, Harpreet; Raza, Azra; Preisler, Harvey D.

In: Leukemia and Lymphoma, Vol. 36, No. 5-6, 01.01.2000, p. 579-587.

Research output: Contribution to journalArticle

Li, B, Yang, J, Andrews, C, Chen, YX, Toofanfard, P, Huang, RW, Horvath, E, Chopra, H, Raza, A & Preisler, HD 2000, 'Telomerase activity in preleukemia and acute myelogenous leukemia', Leukemia and Lymphoma, vol. 36, no. 5-6, pp. 579-587. https://doi.org/10.3109/10428190009148406
Li B, Yang J, Andrews C, Chen YX, Toofanfard P, Huang RW et al. Telomerase activity in preleukemia and acute myelogenous leukemia. Leukemia and Lymphoma. 2000 Jan 1;36(5-6):579-587. https://doi.org/10.3109/10428190009148406
Li, Biaoru ; Yang, Jie ; Andrews, Colleen ; Chen, Yi Xin ; Toofanfard, Paul ; Huang, Ray Win ; Horvath, Erzsebet ; Chopra, Harpreet ; Raza, Azra ; Preisler, Harvey D. / Telomerase activity in preleukemia and acute myelogenous leukemia. In: Leukemia and Lymphoma. 2000 ; Vol. 36, No. 5-6. pp. 579-587.
@article{3ba9998bca7c4a1a986fdec24570e8b6,
title = "Telomerase activity in preleukemia and acute myelogenous leukemia",
abstract = "The development of acute leukemia from preleukemia involves the appearance of clones with increasing proliferative potential. The studies described here demonstrate that telomerase activity progressively increases as the bone marrow cells acquire increasing proliferative potential. This was demonstrated by measuring telomerase activity in normal bone marrow, in post-treatment lymphoma marrows with skewed Lyonization, and in MDS and AML marrows. The greater telomerase activity in myelodysplastic marrow than in normal marrow is not due to a higher proportion of blast cells or to a higher proliferative rate of the MDS marrow. These data demonstrate that the increasing proliferative potential of the marrow which occurs during the development of AML is associated with a simultaneous increase in telomerase activity.",
keywords = "Cell proliferation, Histone H3, Monoclonality, Telomerase, Telomere",
author = "Biaoru Li and Jie Yang and Colleen Andrews and Chen, {Yi Xin} and Paul Toofanfard and Huang, {Ray Win} and Erzsebet Horvath and Harpreet Chopra and Azra Raza and Preisler, {Harvey D.}",
year = "2000",
month = "1",
day = "1",
doi = "10.3109/10428190009148406",
language = "English (US)",
volume = "36",
pages = "579--587",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
publisher = "Informa Healthcare",
number = "5-6",

}

TY - JOUR

T1 - Telomerase activity in preleukemia and acute myelogenous leukemia

AU - Li, Biaoru

AU - Yang, Jie

AU - Andrews, Colleen

AU - Chen, Yi Xin

AU - Toofanfard, Paul

AU - Huang, Ray Win

AU - Horvath, Erzsebet

AU - Chopra, Harpreet

AU - Raza, Azra

AU - Preisler, Harvey D.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - The development of acute leukemia from preleukemia involves the appearance of clones with increasing proliferative potential. The studies described here demonstrate that telomerase activity progressively increases as the bone marrow cells acquire increasing proliferative potential. This was demonstrated by measuring telomerase activity in normal bone marrow, in post-treatment lymphoma marrows with skewed Lyonization, and in MDS and AML marrows. The greater telomerase activity in myelodysplastic marrow than in normal marrow is not due to a higher proportion of blast cells or to a higher proliferative rate of the MDS marrow. These data demonstrate that the increasing proliferative potential of the marrow which occurs during the development of AML is associated with a simultaneous increase in telomerase activity.

AB - The development of acute leukemia from preleukemia involves the appearance of clones with increasing proliferative potential. The studies described here demonstrate that telomerase activity progressively increases as the bone marrow cells acquire increasing proliferative potential. This was demonstrated by measuring telomerase activity in normal bone marrow, in post-treatment lymphoma marrows with skewed Lyonization, and in MDS and AML marrows. The greater telomerase activity in myelodysplastic marrow than in normal marrow is not due to a higher proportion of blast cells or to a higher proliferative rate of the MDS marrow. These data demonstrate that the increasing proliferative potential of the marrow which occurs during the development of AML is associated with a simultaneous increase in telomerase activity.

KW - Cell proliferation

KW - Histone H3

KW - Monoclonality

KW - Telomerase

KW - Telomere

UR - http://www.scopus.com/inward/record.url?scp=0033967047&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033967047&partnerID=8YFLogxK

U2 - 10.3109/10428190009148406

DO - 10.3109/10428190009148406

M3 - Article

VL - 36

SP - 579

EP - 587

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

SN - 1042-8194

IS - 5-6

ER -