Telomerase activity in preleukemia and acute myelogenous leukemia

Biaoru Li, Jie Yang, Colleen Andrews, Yi Xin Chen, Paul Toofanfard, Ray Win Huang, Erzsebet Horvath, Harpreet Chopra, Azra Raza, Harvey D. Preisler

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The development of acute leukemia from preleukemia involves the appearance of clones with increasing proliferative potential. The studies described here demonstrate that telomerase activity progressively increases as the bone marrow cells acquire increasing proliferative potential. This was demonstrated by measuring telomerase activity in normal bone marrow, in post-treatment lymphoma marrows with skewed Lyonization, and in MDS and AML marrows. The greater telomerase activity in myelodysplastic marrow than in normal marrow is not due to a higher proportion of blast cells or to a higher proliferative rate of the MDS marrow. These data demonstrate that the increasing proliferative potential of the marrow which occurs during the development of AML is associated with a simultaneous increase in telomerase activity.

Original languageEnglish (US)
Pages (from-to)579-587
Number of pages9
JournalLeukemia and Lymphoma
Volume36
Issue number5-6
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Keywords

  • Cell proliferation
  • Histone H3
  • Monoclonality
  • Telomerase
  • Telomere

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Li, B., Yang, J., Andrews, C., Chen, Y. X., Toofanfard, P., Huang, R. W., Horvath, E., Chopra, H., Raza, A., & Preisler, H. D. (2000). Telomerase activity in preleukemia and acute myelogenous leukemia. Leukemia and Lymphoma, 36(5-6), 579-587. https://doi.org/10.3109/10428190009148406