Telomere Biology in Senescence and Aging: Focus on Cardiovascular Traits

Haidong Zhu, P. van der Harst

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Aging affects most cells, organisms, and species and is associated with cellular senescence. Cellular senescence inhibits cell proliferation, resulting in irreversible growth arrest, and impairs survival. Susceptibility to various chronic diseases, such as cancer, cardiovascular disease, diabetes mellitus, and neurological diseases increases with aging. Although remarkable progress has been made over the last few decades, our understanding of the aging process is imperfect. Important players in the aging field are telomeres and their regulators. Telomeres not only play an important role in the aging process but have also been linked to a plethora of diseases and conditions unfavorable to health. In this chapter, we will discuss our current understanding of telomere biology and its relation to cardiovascular disease and diabetes.

Original languageEnglish (US)
Title of host publicationInflammation, Advancing Age and Nutrition
Subtitle of host publicationResearch and Clinical Interventions
PublisherElsevier Inc.
Pages71-84
Number of pages14
ISBN (Print)9780123978035
DOIs
StatePublished - Oct 1 2013

Keywords

  • Aging
  • Atherosclerosis
  • Diabetes
  • Heart failure
  • Senescence
  • Telomerase
  • Telomeres

ASJC Scopus subject areas

  • Medicine(all)
  • Dentistry(all)

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    Zhu, H., & van der Harst, P. (2013). Telomere Biology in Senescence and Aging: Focus on Cardiovascular Traits. In Inflammation, Advancing Age and Nutrition: Research and Clinical Interventions (pp. 71-84). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-397803-5.00007-1