Temporal and constitutive expression of homeobox-2 gene (Hu-2), human heat shock gene (hsp-70), and oncogenes C-sis and N-myc in early human trophoblast

Brian C. Su, Dennis Strand, Paul G McDonough, John F. McDonald

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Recent studies of the genetic basis of animal development indicate that homeobox genes, protooncogenes, and some heat shock genes may play a role in early embryogenesis. To investigate the possibility that these genes function in early human embryonic development, we monitored the expression of a human homeobox gene (Hu-2), two human protooncogenes (C-sis and N-myc), and a human heat shock gene (hsp-70) in human trophoblasts at 7 to 13 weeks gestational age. All these genes were found to be expressed in the tissues analyzed. The hsp-70 gene was expressed at nearly constant levels throughout the developmental period surveyed, whereas N-myc, C-sis, and Hu-2 showed a coordinated pattern of regulated expression. These results are consistent with a functional role of these genes in the early course of human development.

Original languageEnglish (US)
Pages (from-to)1195-1199
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume159
Issue number5
DOIs
StatePublished - Jan 1 1988

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sis Genes
Homeobox Genes
Trophoblasts
Shock
Hot Temperature
Genes
Human Development
Embryonic Development
Gestational Age

Keywords

  • Embryogenesis
  • Hu-2
  • hsp-70
  • oncogenes

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Temporal and constitutive expression of homeobox-2 gene (Hu-2), human heat shock gene (hsp-70), and oncogenes C-sis and N-myc in early human trophoblast. / Su, Brian C.; Strand, Dennis; McDonough, Paul G; McDonald, John F.

In: American Journal of Obstetrics and Gynecology, Vol. 159, No. 5, 01.01.1988, p. 1195-1199.

Research output: Contribution to journalArticle

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