Temporal changes in superoxide dismutase, glutathione peroxidase, and catalase levels in primary and peri-ischemic tissue - Monosialoganglioside (GM1) treatment effects

Sahebarao P. Mahadik; Tapas K. Makar; Jayasimha N. Murthy; Astrid Ortiz; Chandramohan G. Wakade; Steven E. Karpiak

doi:10.1007/BF03160018

Temporal changes in superoxide dismutase, glutathione peroxidase, and catalase levels in primary and peri-ischemic tissue - Monosialoganglioside (GM1) treatment effects

Sahebarao P. Mahadik, Tapas K. Makar, Jayasimha N. Murthy, Astrid Ortiz, Chandramohan G. Wakade, Steven E. Karpiak

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Time-dependent changes in levels of the antioxidant enzymes, superoxide dismutasae (SOD), glutathione peroxidase (GSHPOD), and catalase (CAT) after cortical focal ischemia in rat indicate that: (1) primary and peri-ischemic tissues differ in both rate and the magnitude of oxyradical-induced ischemic injury, and (2) ischemic tissue remains vulnerable to oxyradical damage as long as 72 h after ischemia since the antioxidant enzyme levels remain at or below basal levels. After 72h, the increased levels of these enzymes are sufficient to protect tissue against oxyradical damage. GM1 ganglioside (10 mg/kg, im) further increased the already elevated levels of the enzymes after ischemia, thereby indicating the GM1 treatment increases the capacity of ischemic tissue to protect against oxyradical injury.

Original language	English (US)
Pages (from-to)	1-14
Number of pages	14
Journal	Molecular and Chemical Neuropathology
Volume	18
Issue number	1-2
DOIs	https://doi.org/10.1007/BF03160018
State	Published - Jan 1993
Externally published	Yes

Keywords

CNS ischemia
GM1 ganglioside
catalase antioxidant defense
glutathione peroxidase
lipid peroxidation
oxyradical enzymes
superoxide dismutase

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology

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10.1007/BF03160018

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Temporal changes in superoxide dismutase, glutathione peroxidase, and catalase levels in primary and peri-ischemic tissue - Monosialoganglioside (GM1) treatment effects. / Mahadik, Sahebarao P.; Makar, Tapas K.; Murthy, Jayasimha N.; Ortiz, Astrid; Wakade, Chandramohan G.; Karpiak, Steven E.

In: Molecular and Chemical Neuropathology, Vol. 18, No. 1-2, 01.1993, p. 1-14.

Research output: Contribution to journal › Article › peer-review

Mahadik, Sahebarao P. ; Makar, Tapas K. ; Murthy, Jayasimha N. ; Ortiz, Astrid ; Wakade, Chandramohan G. ; Karpiak, Steven E. / Temporal changes in superoxide dismutase, glutathione peroxidase, and catalase levels in primary and peri-ischemic tissue - Monosialoganglioside (GM1) treatment effects. In: Molecular and Chemical Neuropathology. 1993 ; Vol. 18, No. 1-2. pp. 1-14.

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abstract = "Time-dependent changes in levels of the antioxidant enzymes, superoxide dismutasae (SOD), glutathione peroxidase (GSHPOD), and catalase (CAT) after cortical focal ischemia in rat indicate that: (1) primary and peri-ischemic tissues differ in both rate and the magnitude of oxyradical-induced ischemic injury, and (2) ischemic tissue remains vulnerable to oxyradical damage as long as 72 h after ischemia since the antioxidant enzyme levels remain at or below basal levels. After 72h, the increased levels of these enzymes are sufficient to protect tissue against oxyradical damage. GM1 ganglioside (10 mg/kg, im) further increased the already elevated levels of the enzymes after ischemia, thereby indicating the GM1 treatment increases the capacity of ischemic tissue to protect against oxyradical injury.",

keywords = "CNS ischemia, GM1 ganglioside, catalase antioxidant defense, glutathione peroxidase, lipid peroxidation, oxyradical enzymes, superoxide dismutase",

author = "Mahadik, {Sahebarao P.} and Makar, {Tapas K.} and Murthy, {Jayasimha N.} and Astrid Ortiz and Wakade, {Chandramohan G.} and Karpiak, {Steven E.}",

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