Abstract
Time-dependent changes in levels of the antioxidant enzymes, superoxide dismutasae (SOD), glutathione peroxidase (GSHPOD), and catalase (CAT) after cortical focal ischemia in rat indicate that: (1) primary and peri-ischemic tissues differ in both rate and the magnitude of oxyradical-induced ischemic injury, and (2) ischemic tissue remains vulnerable to oxyradical damage as long as 72 h after ischemia since the antioxidant enzyme levels remain at or below basal levels. After 72h, the increased levels of these enzymes are sufficient to protect tissue against oxyradical damage. GM1 ganglioside (10 mg/kg, im) further increased the already elevated levels of the enzymes after ischemia, thereby indicating the GM1 treatment increases the capacity of ischemic tissue to protect against oxyradical injury.
Original language | English (US) |
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Pages (from-to) | 1-14 |
Number of pages | 14 |
Journal | Molecular and Chemical Neuropathology |
Volume | 18 |
Issue number | 1-2 |
DOIs | |
State | Published - Jan 1993 |
Externally published | Yes |
Keywords
- CNS ischemia
- GM1 ganglioside
- catalase antioxidant defense
- glutathione peroxidase
- lipid peroxidation
- oxyradical enzymes
- superoxide dismutase
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology