Temporal changes in superoxide dismutase, glutathione peroxidase, and catalase levels in primary and peri-ischemic tissue - Monosialoganglioside (GM1) treatment effects

Sahebarao P. Mahadik; Tapas K. Makar; Jayasimha N. Murthy; Astrid Ortiz; Chandramohan G. Wakade; Steven E. Karpiak

doi:10.1007/BF03160018

Temporal changes in superoxide dismutase, glutathione peroxidase, and catalase levels in primary and peri-ischemic tissue - Monosialoganglioside (GM1) treatment effects

Sahebarao P. Mahadik, Tapas K. Makar, Jayasimha N. Murthy, Astrid Ortiz, Chandramohan G. Wakade, Steven E. Karpiak

Research output: Contribution to journal › Article

33 Scopus citations

Abstract

Time-dependent changes in levels of the antioxidant enzymes, superoxide dismutasae (SOD), glutathione peroxidase (GSHPOD), and catalase (CAT) after cortical focal ischemia in rat indicate that: (1) primary and peri-ischemic tissues differ in both rate and the magnitude of oxyradical-induced ischemic injury, and (2) ischemic tissue remains vulnerable to oxyradical damage as long as 72 h after ischemia since the antioxidant enzyme levels remain at or below basal levels. After 72h, the increased levels of these enzymes are sufficient to protect tissue against oxyradical damage. GM1 ganglioside (10 mg/kg, im) further increased the already elevated levels of the enzymes after ischemia, thereby indicating the GM1 treatment increases the capacity of ischemic tissue to protect against oxyradical injury.

Original language	English (US)
Pages (from-to)	1-14
Number of pages	14
Journal	Molecular and Chemical Neuropathology
Volume	18
Issue number	1-2
DOIs	https://doi.org/10.1007/BF03160018
State	Published - Jan 1 1993
Externally published	Yes

Keywords

CNS ischemia
GM1 ganglioside
catalase antioxidant defense
glutathione peroxidase
lipid peroxidation
oxyradical enzymes
superoxide dismutase

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology

Access to Document

10.1007/BF03160018

Fingerprint Dive into the research topics of 'Temporal changes in superoxide dismutase, glutathione peroxidase, and catalase levels in primary and peri-ischemic tissue - Monosialoganglioside (GM1) treatment effects'. Together they form a unique fingerprint.

Cite this

Mahadik, S. P., Makar, T. K., Murthy, J. N., Ortiz, A., Wakade, C. G., & Karpiak, S. E. (1993). Temporal changes in superoxide dismutase, glutathione peroxidase, and catalase levels in primary and peri-ischemic tissue - Monosialoganglioside (GM1) treatment effects. Molecular and Chemical Neuropathology, 18(1-2), 1-14. https://doi.org/10.1007/BF03160018

Temporal changes in superoxide dismutase, glutathione peroxidase, and catalase levels in primary and peri-ischemic tissue - Monosialoganglioside (GM1) treatment effects. / Mahadik, Sahebarao P.; Makar, Tapas K.; Murthy, Jayasimha N.; Ortiz, Astrid; Wakade, Chandramohan G.; Karpiak, Steven E.

In: Molecular and Chemical Neuropathology, Vol. 18, No. 1-2, 01.01.1993, p. 1-14.

Research output: Contribution to journal › Article

Mahadik, Sahebarao P. ; Makar, Tapas K. ; Murthy, Jayasimha N. ; Ortiz, Astrid ; Wakade, Chandramohan G. ; Karpiak, Steven E. / Temporal changes in superoxide dismutase, glutathione peroxidase, and catalase levels in primary and peri-ischemic tissue - Monosialoganglioside (GM1) treatment effects. In: Molecular and Chemical Neuropathology. 1993 ; Vol. 18, No. 1-2. pp. 1-14.

@article{f035a7827353461d97683a68cf90e8dd,

title = "Temporal changes in superoxide dismutase, glutathione peroxidase, and catalase levels in primary and peri-ischemic tissue - Monosialoganglioside (GM1) treatment effects",

abstract = "Time-dependent changes in levels of the antioxidant enzymes, superoxide dismutasae (SOD), glutathione peroxidase (GSHPOD), and catalase (CAT) after cortical focal ischemia in rat indicate that: (1) primary and peri-ischemic tissues differ in both rate and the magnitude of oxyradical-induced ischemic injury, and (2) ischemic tissue remains vulnerable to oxyradical damage as long as 72 h after ischemia since the antioxidant enzyme levels remain at or below basal levels. After 72h, the increased levels of these enzymes are sufficient to protect tissue against oxyradical damage. GM1 ganglioside (10 mg/kg, im) further increased the already elevated levels of the enzymes after ischemia, thereby indicating the GM1 treatment increases the capacity of ischemic tissue to protect against oxyradical injury.",

keywords = "CNS ischemia, GM1 ganglioside, catalase antioxidant defense, glutathione peroxidase, lipid peroxidation, oxyradical enzymes, superoxide dismutase",

author = "Mahadik, {Sahebarao P.} and Makar, {Tapas K.} and Murthy, {Jayasimha N.} and Astrid Ortiz and Wakade, {Chandramohan G.} and Karpiak, {Steven E.}",

year = "1993",

month = jan,

day = "1",

doi = "10.1007/BF03160018",

language = "English (US)",

volume = "18",

pages = "1--14",

journal = "Journal of Molecular Neuroscience",

issn = "0895-8696",

publisher = "Humana Press",

number = "1-2",

}

TY - JOUR

T1 - Temporal changes in superoxide dismutase, glutathione peroxidase, and catalase levels in primary and peri-ischemic tissue - Monosialoganglioside (GM1) treatment effects

AU - Mahadik, Sahebarao P.

AU - Makar, Tapas K.

AU - Murthy, Jayasimha N.

AU - Ortiz, Astrid

AU - Wakade, Chandramohan G.

AU - Karpiak, Steven E.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Time-dependent changes in levels of the antioxidant enzymes, superoxide dismutasae (SOD), glutathione peroxidase (GSHPOD), and catalase (CAT) after cortical focal ischemia in rat indicate that: (1) primary and peri-ischemic tissues differ in both rate and the magnitude of oxyradical-induced ischemic injury, and (2) ischemic tissue remains vulnerable to oxyradical damage as long as 72 h after ischemia since the antioxidant enzyme levels remain at or below basal levels. After 72h, the increased levels of these enzymes are sufficient to protect tissue against oxyradical damage. GM1 ganglioside (10 mg/kg, im) further increased the already elevated levels of the enzymes after ischemia, thereby indicating the GM1 treatment increases the capacity of ischemic tissue to protect against oxyradical injury.

AB - Time-dependent changes in levels of the antioxidant enzymes, superoxide dismutasae (SOD), glutathione peroxidase (GSHPOD), and catalase (CAT) after cortical focal ischemia in rat indicate that: (1) primary and peri-ischemic tissues differ in both rate and the magnitude of oxyradical-induced ischemic injury, and (2) ischemic tissue remains vulnerable to oxyradical damage as long as 72 h after ischemia since the antioxidant enzyme levels remain at or below basal levels. After 72h, the increased levels of these enzymes are sufficient to protect tissue against oxyradical damage. GM1 ganglioside (10 mg/kg, im) further increased the already elevated levels of the enzymes after ischemia, thereby indicating the GM1 treatment increases the capacity of ischemic tissue to protect against oxyradical injury.

KW - CNS ischemia

KW - GM1 ganglioside

KW - catalase antioxidant defense

KW - glutathione peroxidase

KW - lipid peroxidation

KW - oxyradical enzymes

KW - superoxide dismutase

UR - http://www.scopus.com/inward/record.url?scp=0027191063&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027191063&partnerID=8YFLogxK

U2 - 10.1007/BF03160018

DO - 10.1007/BF03160018

M3 - Article

C2 - 8466585

AN - SCOPUS:0027191063

VL - 18

SP - 1

EP - 14

JO - Journal of Molecular Neuroscience

JF - Journal of Molecular Neuroscience

SN - 0895-8696

IS - 1-2

ER -