Temporal changes in superoxide dismutase, glutathione peroxidase, and catalase levels in primary and peri-ischemic tissue - Monosialoganglioside (GM1) treatment effects

Sahebarao P. Mahadik, Tapas K. Makar, Jayasimha N. Murthy, Astrid Ortiz, Chandramohan G. Wakade, Steven E. Karpiak

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Time-dependent changes in levels of the antioxidant enzymes, superoxide dismutasae (SOD), glutathione peroxidase (GSHPOD), and catalase (CAT) after cortical focal ischemia in rat indicate that: (1) primary and peri-ischemic tissues differ in both rate and the magnitude of oxyradical-induced ischemic injury, and (2) ischemic tissue remains vulnerable to oxyradical damage as long as 72 h after ischemia since the antioxidant enzyme levels remain at or below basal levels. After 72h, the increased levels of these enzymes are sufficient to protect tissue against oxyradical damage. GM1 ganglioside (10 mg/kg, im) further increased the already elevated levels of the enzymes after ischemia, thereby indicating the GM1 treatment increases the capacity of ischemic tissue to protect against oxyradical injury.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalMolecular and Chemical Neuropathology
Volume18
Issue number1-2
DOIs
StatePublished - Jan 1993
Externally publishedYes

Keywords

  • CNS ischemia
  • GM1 ganglioside
  • catalase antioxidant defense
  • glutathione peroxidase
  • lipid peroxidation
  • oxyradical enzymes
  • superoxide dismutase

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology

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