Temporal dynamics of distinct CA1 cell populations during unconscious state induced by ketamine

Hui Kuang, Longnian Lin, Joe Z. Tsien

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Ketamine is a widely used dissociative anesthetic which can induce some psychotic-like symptoms and memory deficits in some patients during the post-operative period. To understand its effects on neural population dynamics in the brain, we employed large-scale in vivo ensemble recording techniques to monitor the activity patterns of simultaneously recorded hippocampal CA1 pyramidal cells and various interneurons during several conscious and unconscious states such as awake rest, running, slow wave sleep, and ketamine-induced anesthesia. Our analyses reveal that ketamine induces distinct oscillatory dynamics not only in pyramidal cells but also in at least seven different types of CA1 interneurons including putative basket cells, chandelier cells, bistratified cells, and O-LM cells. These emergent unique oscillatory dynamics may very well reflect the intrinsic temporal relationships within the CA1 circuit. It is conceivable that systematic characterization of network dynamics may eventually lead to better understanding of how ketamine induces unconsciousness and consequently alters the conscious mind.

Original languageEnglish (US)
Article numbere15209
JournalPloS one
Volume5
Issue number12
DOIs
StatePublished - Dec 20 2010

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Unconsciousness
Ketamine
ketamine
Cells
Pyramidal Cells
Interneurons
Population
Dissociative Anesthetics
interneurons
cells
Population dynamics
Memory Disorders
Population Dynamics
unconsciousness
Brain
Sleep
Anesthesia
sleep
Data storage equipment
anesthetics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Temporal dynamics of distinct CA1 cell populations during unconscious state induced by ketamine. / Kuang, Hui; Lin, Longnian; Tsien, Joe Z.

In: PloS one, Vol. 5, No. 12, e15209, 20.12.2010.

Research output: Contribution to journalArticle

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