Tensilon and the diagnosis of myasthenia gravis

Are we using the tensilon test too much?

Michael S. Okun, Christina M. Charriez, M. Tariq Bhatti, Robert T. Watson, Thomas Robert Swift

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

BACKGROUND- Tensilon (edrophonium chloride) is a reversible acetylcholinesterase inhibitor used in the diagnosis of myasthenia gravis, diagnosis and treatment of arrhythmias, detection of early digitalis toxicity, reversal of neuromuscular blockade, and other medical conditions. Toxicity associated with Tensilon use has appeared in the literature for decades. REVIEW SUMMARY- This review discusses the risks of Tensilon and the information practitioners should know before administering the drug. We review the literature regarding serious toxicity of this drug and offer recommendations for its safe use. CONCLUSIONS- A careful medication history should be taken before the administration of Tensilon. Additionally, physicians should be aware of appropriate alternative methods of diagnosis before choosing to administer Tensilon. Physicians should be aware of the clinical situations where the Tensilon test no longer is indicated.

Original languageEnglish (US)
Pages (from-to)295-299
Number of pages5
JournalNeurologist
Volume7
Issue number5
DOIs
StatePublished - Jan 1 2001

Fingerprint

Edrophonium
Myasthenia Gravis
Physicians
Neuromuscular Blockade
Digitalis
Cholinesterase Inhibitors
Drug-Related Side Effects and Adverse Reactions
Cardiac Arrhythmias

Keywords

  • Cardiac
  • Diagnosis
  • Myasthenia
  • Neurologic
  • Review
  • Tensilon

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Tensilon and the diagnosis of myasthenia gravis : Are we using the tensilon test too much? / Okun, Michael S.; Charriez, Christina M.; Bhatti, M. Tariq; Watson, Robert T.; Swift, Thomas Robert.

In: Neurologist, Vol. 7, No. 5, 01.01.2001, p. 295-299.

Research output: Contribution to journalReview article

Okun, Michael S. ; Charriez, Christina M. ; Bhatti, M. Tariq ; Watson, Robert T. ; Swift, Thomas Robert. / Tensilon and the diagnosis of myasthenia gravis : Are we using the tensilon test too much?. In: Neurologist. 2001 ; Vol. 7, No. 5. pp. 295-299.
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