Ternary condensation of Biginelli thiones, chloroacetic acid, and aldehydes as an effective approach towards thiazolo[3,2-a] pyrimidines and 5-arylidenethiazolidine-2,4-diones

Iryna Oleksandrivna Lebedyeva, Mykhaylo V. Povstyanoy, Aleksey B. Ryabitskii, Vyacheslav M. Povstyanoy

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

(Chemical Equation Presented) At the process of ethyl 6-methyl-4-aryl-2- thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates condensation with aryl aldehydes and chloroacetic acid the unexpected formation of 5- arylidenethiazolidine-2,4-diones was determined in high yields as the reaction time was increased to 20 h. The latter represent the products of destructive hydrolyzes of ethyl 2-benzylidene-7-methyl-3-oxo-5-aryl-2,3-dihydro-5H-[1,3] thiazolo[3,2-a]pyrimidine-6-carboxylates which have been proved by independent synthesis.

Original languageEnglish (US)
Pages (from-to)368-372
Number of pages5
JournalJournal of Heterocyclic Chemistry
Volume47
Issue number2
DOIs
StatePublished - Mar 1 2010
Externally publishedYes

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Thiones
Pyrimidines
Aldehydes
Condensation
chloroacetic acid
pyrimidine

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Ternary condensation of Biginelli thiones, chloroacetic acid, and aldehydes as an effective approach towards thiazolo[3,2-a] pyrimidines and 5-arylidenethiazolidine-2,4-diones. / Lebedyeva, Iryna Oleksandrivna; Povstyanoy, Mykhaylo V.; Ryabitskii, Aleksey B.; Povstyanoy, Vyacheslav M.

In: Journal of Heterocyclic Chemistry, Vol. 47, No. 2, 01.03.2010, p. 368-372.

Research output: Contribution to journalArticle

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