Abstract
(Chemical Equation Presented) At the process of ethyl 6-methyl-4-aryl-2- thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates condensation with aryl aldehydes and chloroacetic acid the unexpected formation of 5- arylidenethiazolidine-2,4-diones was determined in high yields as the reaction time was increased to 20 h. The latter represent the products of destructive hydrolyzes of ethyl 2-benzylidene-7-methyl-3-oxo-5-aryl-2,3-dihydro-5H-[1,3] thiazolo[3,2-a]pyrimidine-6-carboxylates which have been proved by independent synthesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 368-372 |
| Number of pages | 5 |
| Journal | Journal of Heterocyclic Chemistry |
| Volume | 47 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 1 2010 |
| Externally published | Yes |
ASJC Scopus subject areas
- Organic Chemistry
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Cite this
Lebedyeva, I. O., Povstyanoy, M. V., Ryabitskii, A. B., & Povstyanoy, V. M. (2010). Ternary condensation of Biginelli thiones, chloroacetic acid, and aldehydes as an effective approach towards thiazolo[3,2-a] pyrimidines and 5-arylidenethiazolidine-2,4-diones. Journal of Heterocyclic Chemistry, 47(2), 368-372. https://doi.org/10.1002/jhet.323