Test of cure for genital Chlamydia trachomatis infection in women

Daron Gale Ferris, F. H. Lawler, R. D. Horner, J. C. Jernigan, F. V. Crout

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Convenient, reliable tests of cure for genital chlamydial infections have not been evaluated. Cervical appearance, endocervical Gram stain, enzyme immunoassay, and culture for Chlamydia trachomatis were evaluated during a pretreatment visit and at two subsequent randomized test-of-cure visits for 64 nongravid women with endocervical C trachomatis of 3544 patients screened. There were no useful correlations between C trachomatis resolution and cervical appearance. Endocervical Gram stain was determined to be unreliable for test-of-cure use. Both C trachomatis culture and enzyme-linked immunosorbent assay (ELISA) were shown to be effective for test-of-cure evaluation. The ELISA test became reliably negative 10 days after initiation of treatment and 1 to 5 days after the clearance of viable organisms detected by culture (P = .03). Convenience and cost considerations favor antigen detection methods. This study suggests that antigen detection methods can be used for situations in which test of cure is indicated, such as therapy noncompliance, circumstances supporting reinfection, pregnancy, complicated infections, requests for psychological reassurance, and evidence of persistent cervicitis.

Original languageEnglish (US)
Pages (from-to)36-41
Number of pages6
JournalJournal of Family Practice
Volume31
Issue number1
StatePublished - Jan 1 1990

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Chlamydia Infections
Chlamydia trachomatis
Enzyme-Linked Immunosorbent Assay
Uterine Cervicitis
Antigens
Infection
Immunoenzyme Techniques
Psychology
Costs and Cost Analysis
Pregnancy
Therapeutics
Gram's stain

ASJC Scopus subject areas

  • Family Practice

Cite this

Ferris, D. G., Lawler, F. H., Horner, R. D., Jernigan, J. C., & Crout, F. V. (1990). Test of cure for genital Chlamydia trachomatis infection in women. Journal of Family Practice, 31(1), 36-41.

Test of cure for genital Chlamydia trachomatis infection in women. / Ferris, Daron Gale; Lawler, F. H.; Horner, R. D.; Jernigan, J. C.; Crout, F. V.

In: Journal of Family Practice, Vol. 31, No. 1, 01.01.1990, p. 36-41.

Research output: Contribution to journalArticle

Ferris, DG, Lawler, FH, Horner, RD, Jernigan, JC & Crout, FV 1990, 'Test of cure for genital Chlamydia trachomatis infection in women', Journal of Family Practice, vol. 31, no. 1, pp. 36-41.
Ferris DG, Lawler FH, Horner RD, Jernigan JC, Crout FV. Test of cure for genital Chlamydia trachomatis infection in women. Journal of Family Practice. 1990 Jan 1;31(1):36-41.
Ferris, Daron Gale ; Lawler, F. H. ; Horner, R. D. ; Jernigan, J. C. ; Crout, F. V. / Test of cure for genital Chlamydia trachomatis infection in women. In: Journal of Family Practice. 1990 ; Vol. 31, No. 1. pp. 36-41.
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