TGF-β/BMP signaling in cartilage and bone cells

Mei Wan, Xing Ming Shi, Xu Cao

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Cartilage and bone formation, a continual process in both vertebrate development and adult bone remodeling, is regulated by many growth factorq 64s. Transforming Growth Factors (TGF-βs) and Bone Morphogenetic Proteins (BMPs), members of the TGF-β superfamily, are the most potent regulators of chondrocyte and osteoblast differentiation among the local factors governing the process of biomineralization. To gain a better understanding of the molecular mechanisms underlying the role of TGF-β/BMP in normal cartilage and bone formation, as well as in cartilage and bone diseases, it is necessary to clarify the TGF-β/BMP signaling transduction pathways in chondrocytes and osteoblasts. Thus far, primary signaling cascades downstream of the TGF-β/BMP have been elucidated. The major objective of this review is to summarize the TGF-β/BMP signaling pathways in chondrocytes and osteoblasts. In particular, this discourse will focus on recent advances of the role of different ligands, receptors, Smads and Smad-interacting transcription factors in cartilage and bone formation during embryonic development and postnatal osteogenesis.

Original languageEnglish (US)
Pages (from-to)368-374
Number of pages7
JournalCurrent Opinion in Orthopaedics
Volume13
Issue number5
DOIs
StatePublished - Oct 1 2002
Externally publishedYes

Fingerprint

Bone Morphogenetic Proteins
Cartilage
Osteogenesis
Bone and Bones
Chondrocytes
Osteoblasts
Cartilage Diseases
Bone Remodeling
Bone Diseases
Transforming Growth Factors
Embryonic Development
Vertebrates
Transcription Factors
Ligands
Growth

ASJC Scopus subject areas

  • Surgery

Cite this

TGF-β/BMP signaling in cartilage and bone cells. / Wan, Mei; Shi, Xing Ming; Cao, Xu.

In: Current Opinion in Orthopaedics, Vol. 13, No. 5, 01.10.2002, p. 368-374.

Research output: Contribution to journalReview article

Wan, Mei ; Shi, Xing Ming ; Cao, Xu. / TGF-β/BMP signaling in cartilage and bone cells. In: Current Opinion in Orthopaedics. 2002 ; Vol. 13, No. 5. pp. 368-374.
@article{e2066eac538b45448e7c9a84d6b981b4,
title = "TGF-β/BMP signaling in cartilage and bone cells",
abstract = "Cartilage and bone formation, a continual process in both vertebrate development and adult bone remodeling, is regulated by many growth factorq 64s. Transforming Growth Factors (TGF-βs) and Bone Morphogenetic Proteins (BMPs), members of the TGF-β superfamily, are the most potent regulators of chondrocyte and osteoblast differentiation among the local factors governing the process of biomineralization. To gain a better understanding of the molecular mechanisms underlying the role of TGF-β/BMP in normal cartilage and bone formation, as well as in cartilage and bone diseases, it is necessary to clarify the TGF-β/BMP signaling transduction pathways in chondrocytes and osteoblasts. Thus far, primary signaling cascades downstream of the TGF-β/BMP have been elucidated. The major objective of this review is to summarize the TGF-β/BMP signaling pathways in chondrocytes and osteoblasts. In particular, this discourse will focus on recent advances of the role of different ligands, receptors, Smads and Smad-interacting transcription factors in cartilage and bone formation during embryonic development and postnatal osteogenesis.",
author = "Mei Wan and Shi, {Xing Ming} and Xu Cao",
year = "2002",
month = "10",
day = "1",
doi = "10.1097/00001433-200210000-00007",
language = "English (US)",
volume = "13",
pages = "368--374",
journal = "Current Orthopaedic Practice",
issn = "1940-7041",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - TGF-β/BMP signaling in cartilage and bone cells

AU - Wan, Mei

AU - Shi, Xing Ming

AU - Cao, Xu

PY - 2002/10/1

Y1 - 2002/10/1

N2 - Cartilage and bone formation, a continual process in both vertebrate development and adult bone remodeling, is regulated by many growth factorq 64s. Transforming Growth Factors (TGF-βs) and Bone Morphogenetic Proteins (BMPs), members of the TGF-β superfamily, are the most potent regulators of chondrocyte and osteoblast differentiation among the local factors governing the process of biomineralization. To gain a better understanding of the molecular mechanisms underlying the role of TGF-β/BMP in normal cartilage and bone formation, as well as in cartilage and bone diseases, it is necessary to clarify the TGF-β/BMP signaling transduction pathways in chondrocytes and osteoblasts. Thus far, primary signaling cascades downstream of the TGF-β/BMP have been elucidated. The major objective of this review is to summarize the TGF-β/BMP signaling pathways in chondrocytes and osteoblasts. In particular, this discourse will focus on recent advances of the role of different ligands, receptors, Smads and Smad-interacting transcription factors in cartilage and bone formation during embryonic development and postnatal osteogenesis.

AB - Cartilage and bone formation, a continual process in both vertebrate development and adult bone remodeling, is regulated by many growth factorq 64s. Transforming Growth Factors (TGF-βs) and Bone Morphogenetic Proteins (BMPs), members of the TGF-β superfamily, are the most potent regulators of chondrocyte and osteoblast differentiation among the local factors governing the process of biomineralization. To gain a better understanding of the molecular mechanisms underlying the role of TGF-β/BMP in normal cartilage and bone formation, as well as in cartilage and bone diseases, it is necessary to clarify the TGF-β/BMP signaling transduction pathways in chondrocytes and osteoblasts. Thus far, primary signaling cascades downstream of the TGF-β/BMP have been elucidated. The major objective of this review is to summarize the TGF-β/BMP signaling pathways in chondrocytes and osteoblasts. In particular, this discourse will focus on recent advances of the role of different ligands, receptors, Smads and Smad-interacting transcription factors in cartilage and bone formation during embryonic development and postnatal osteogenesis.

UR - http://www.scopus.com/inward/record.url?scp=0036788212&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036788212&partnerID=8YFLogxK

U2 - 10.1097/00001433-200210000-00007

DO - 10.1097/00001433-200210000-00007

M3 - Review article

VL - 13

SP - 368

EP - 374

JO - Current Orthopaedic Practice

JF - Current Orthopaedic Practice

SN - 1940-7041

IS - 5

ER -