TGF-β/BMP signaling in cartilage and bone cells

Mei Wan, Xingming Shi, Xu Cao

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Cartilage and bone formation, a continual process in both vertebrate development and adult bone remodeling, is regulated by many growth factorq 64s. Transforming Growth Factors (TGF-βs) and Bone Morphogenetic Proteins (BMPs), members of the TGF-β superfamily, are the most potent regulators of chondrocyte and osteoblast differentiation among the local factors governing the process of biomineralization. To gain a better understanding of the molecular mechanisms underlying the role of TGF-β/BMP in normal cartilage and bone formation, as well as in cartilage and bone diseases, it is necessary to clarify the TGF-β/BMP signaling transduction pathways in chondrocytes and osteoblasts. Thus far, primary signaling cascades downstream of the TGF-β/BMP have been elucidated. The major objective of this review is to summarize the TGF-β/BMP signaling pathways in chondrocytes and osteoblasts. In particular, this discourse will focus on recent advances of the role of different ligands, receptors, Smads and Smad-interacting transcription factors in cartilage and bone formation during embryonic development and postnatal osteogenesis.

Original languageEnglish (US)
Pages (from-to)368-374
Number of pages7
JournalCurrent Opinion in Orthopaedics
Volume13
Issue number5
DOIs
StatePublished - Oct 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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