Abstract
The α4β1 integrin is an adhesion receptor expressed on reticulocytes in sickle cell disease (SCD) and mediates the adhesion of these cells to sub-endothelial matrix proteins and the endothelium. In this review, we describe the mechanism of activation of the α4β1 integrin on sickle reticulocytes and discuss novel roles for this integrin in SCD as a result of this activation. We also illustrate novel therapies in SCD that may target the integrin and alleviate vaso-occlusion.
Original language | English (US) |
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Pages (from-to) | 19-22 |
Number of pages | 4 |
Journal | Transfusion Clinique et Biologique |
Volume | 15 |
Issue number | 1-2 |
DOIs | |
State | Published - Feb 2008 |
Externally published | Yes |
Keywords
- Adhesion molecules
- Sickle cell disease
- Vaso-occlusion
- α4β1 integrin activation
ASJC Scopus subject areas
- Hematology
- Clinical Biochemistry
- Biochemistry, medical