TY - JOUR
T1 - The 'β-like-globin' gene domain in human erythroid cells
AU - Tuan Lo, Dorothy
AU - Solomon, W.
AU - Li, Q.
AU - London, I. M.
PY - 1985
Y1 - 1985
N2 - We have mapped the distribution of the major and minor DNase I-hypersensitive sites in the human 'β-like-globin' gene domain. The minor DNase I-hypersensitive sites map close to the 5' end of each of the β-like-globin genes. Their presence is specifically associated with the transcription of the immediate downstream β-like-globin genes. The major DNase I-hypersensitive sites map in what appear to be the 5' and 3' boundary areas of the human β-like-globin gene domain, a region estimated to span at least 90 kilobases of DNA. These major sites are present in various erythroid cells, which express predominantly either the embryonic, the fetal, or the adult β-like-globin genes, and seem to be involved in defining the active β-like-globin gene domain in cells of erythroid lineage. The four major DNase I-hypersensitive sites in the 5' boundary area, when correlated with sequencing data, are shown to be located in DNA regions containing enhancer core-like sequences and alternating purine and pyrimidine bases.
AB - We have mapped the distribution of the major and minor DNase I-hypersensitive sites in the human 'β-like-globin' gene domain. The minor DNase I-hypersensitive sites map close to the 5' end of each of the β-like-globin genes. Their presence is specifically associated with the transcription of the immediate downstream β-like-globin genes. The major DNase I-hypersensitive sites map in what appear to be the 5' and 3' boundary areas of the human β-like-globin gene domain, a region estimated to span at least 90 kilobases of DNA. These major sites are present in various erythroid cells, which express predominantly either the embryonic, the fetal, or the adult β-like-globin genes, and seem to be involved in defining the active β-like-globin gene domain in cells of erythroid lineage. The four major DNase I-hypersensitive sites in the 5' boundary area, when correlated with sequencing data, are shown to be located in DNA regions containing enhancer core-like sequences and alternating purine and pyrimidine bases.
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U2 - 10.1073/pnas.82.19.6384
DO - 10.1073/pnas.82.19.6384
M3 - Article
C2 - 3879975
AN - SCOPUS:0344272073
SN - 0027-8424
VL - 82
SP - 6384
EP - 6388
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 19
ER -