The 5-HT3 receptor antagonist, RS-56812, enhances delayed matching performance in monkeys

Alvin V. Terry, Jerry J. Buccafusco, Mark A. Prendergast, William J. Jackson, David L. Fontana, Erik H F Wong, Roger L. Whiting, Richard M. Eglen

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

SUBSTANTIAL evidence indicates that serotonin receptors are involved in the regulation of acetylcholine release in CNS regions important to mnemonic processes, and may thus be exploited pharmacologically as targets for memory improvement. In the present study, the (R) and (S) isomers of a potent serotonin (5-HT3) receptor ligand, RS-56812 were evaluated for potential memory effects in five macaques trained to perform a delayed matching-to-sample (DMTS) task. While both isomers enhanced certain aspects of task performance, the (R) isomer produced more systematic improvements. This differential sensitivity to the isomers in regard to DMTS performance appears to parallel the higher 5-HT3 receptor affinity of the R enanantiomer. The results are consistent with a potential therapeutic role for RS-56812 in disorders involving cognitive decline.

Original languageEnglish (US)
Pages (from-to)49-54
Number of pages6
JournalNeuroReport
Volume8
Issue number1
DOIs
StatePublished - Dec 20 1996

Keywords

  • 5HT receptors
  • Acetylcholine
  • Matching to sample
  • Memory
  • Monkey
  • Receptors
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)

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    Terry, A. V., Buccafusco, J. J., Prendergast, M. A., Jackson, W. J., Fontana, D. L., Wong, E. H. F., Whiting, R. L., & Eglen, R. M. (1996). The 5-HT3 receptor antagonist, RS-56812, enhances delayed matching performance in monkeys. NeuroReport, 8(1), 49-54. https://doi.org/10.1097/00001756-199612200-00011