The 5-HT3 receptor antagonist, RS-56812, enhances delayed matching performance in monkeys

Alvin V. Terry, Jerry J. Buccafusco, Mark A. Prendergast, William J. Jackson, David L. Fontana, Erik H F Wong, Roger L. Whiting, Richard M. Eglen

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

SUBSTANTIAL evidence indicates that serotonin receptors are involved in the regulation of acetylcholine release in CNS regions important to mnemonic processes, and may thus be exploited pharmacologically as targets for memory improvement. In the present study, the (R) and (S) isomers of a potent serotonin (5-HT3) receptor ligand, RS-56812 were evaluated for potential memory effects in five macaques trained to perform a delayed matching-to-sample (DMTS) task. While both isomers enhanced certain aspects of task performance, the (R) isomer produced more systematic improvements. This differential sensitivity to the isomers in regard to DMTS performance appears to parallel the higher 5-HT3 receptor affinity of the R enanantiomer. The results are consistent with a potential therapeutic role for RS-56812 in disorders involving cognitive decline.

Original languageEnglish (US)
Pages (from-to)49-54
Number of pages6
JournalNeuroReport
Volume8
Issue number1
DOIs
StatePublished - Dec 20 1996

Fingerprint

Serotonin 5-HT3 Receptor Antagonists
Receptors, Serotonin, 5-HT3
Haplorhini
Serotonin Receptors
Task Performance and Analysis
Macaca
Acetylcholine
Ligands
RS 56812
Therapeutics

Keywords

  • 5HT receptors
  • Acetylcholine
  • Matching to sample
  • Memory
  • Monkey
  • Receptors
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Terry, A. V., Buccafusco, J. J., Prendergast, M. A., Jackson, W. J., Fontana, D. L., Wong, E. H. F., ... Eglen, R. M. (1996). The 5-HT3 receptor antagonist, RS-56812, enhances delayed matching performance in monkeys. NeuroReport, 8(1), 49-54. https://doi.org/10.1097/00001756-199612200-00011

The 5-HT3 receptor antagonist, RS-56812, enhances delayed matching performance in monkeys. / Terry, Alvin V.; Buccafusco, Jerry J.; Prendergast, Mark A.; Jackson, William J.; Fontana, David L.; Wong, Erik H F; Whiting, Roger L.; Eglen, Richard M.

In: NeuroReport, Vol. 8, No. 1, 20.12.1996, p. 49-54.

Research output: Contribution to journalArticle

Terry, AV, Buccafusco, JJ, Prendergast, MA, Jackson, WJ, Fontana, DL, Wong, EHF, Whiting, RL & Eglen, RM 1996, 'The 5-HT3 receptor antagonist, RS-56812, enhances delayed matching performance in monkeys', NeuroReport, vol. 8, no. 1, pp. 49-54. https://doi.org/10.1097/00001756-199612200-00011
Terry, Alvin V. ; Buccafusco, Jerry J. ; Prendergast, Mark A. ; Jackson, William J. ; Fontana, David L. ; Wong, Erik H F ; Whiting, Roger L. ; Eglen, Richard M. / The 5-HT3 receptor antagonist, RS-56812, enhances delayed matching performance in monkeys. In: NeuroReport. 1996 ; Vol. 8, No. 1. pp. 49-54.
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