The actions of 2-hydroxy-saclofen at presynaptic GABAB receptors in the rat hippocampus

Neil L. Harrison, David M. Lovinger, Nevin A Lambert, Timothy J. Teyler, Rolf Prager, Jennifer Ong, David I.B. Kerr

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The actions of 2-hydroxy-saclofen (2-OH-S), a recently develoepd analog of baclofen, were studied at presynaptic GABAB receptors in the rat hippocampal slice. Baclofen (0.5-20 μM) reduces the amplitude of excitatory postsynaptic potentials (EPSPs) recorded from hippocampal CA1 pyramidal neurons. In the presence of 200-500 μM 2-OH-S, the synaptic depressant action of baclofen is significantly reduced. These data show that 2-OH-S is an effective antagonist at presynaptic GABAB receptors on excitatory terminals in the hippocampus.

Original languageEnglish (US)
Pages (from-to)272-276
Number of pages5
JournalNeuroscience Letters
Volume119
Issue number2
DOIs
StatePublished - Nov 13 1990
Externally publishedYes

Fingerprint

Presynaptic Receptors
Baclofen
Hippocampus
Pyramidal Cells
Excitatory Postsynaptic Potentials
2-hydroxysaclofen
hydroxide ion

Keywords

  • 2-Hydroxysaclofen
  • GABA receptor
  • Hippocampus
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Harrison, N. L., Lovinger, D. M., Lambert, N. A., Teyler, T. J., Prager, R., Ong, J., & Kerr, D. I. B. (1990). The actions of 2-hydroxy-saclofen at presynaptic GABAB receptors in the rat hippocampus. Neuroscience Letters, 119(2), 272-276. https://doi.org/10.1016/0304-3940(90)90851-Y

The actions of 2-hydroxy-saclofen at presynaptic GABAB receptors in the rat hippocampus. / Harrison, Neil L.; Lovinger, David M.; Lambert, Nevin A; Teyler, Timothy J.; Prager, Rolf; Ong, Jennifer; Kerr, David I.B.

In: Neuroscience Letters, Vol. 119, No. 2, 13.11.1990, p. 272-276.

Research output: Contribution to journalArticle

Harrison, NL, Lovinger, DM, Lambert, NA, Teyler, TJ, Prager, R, Ong, J & Kerr, DIB 1990, 'The actions of 2-hydroxy-saclofen at presynaptic GABAB receptors in the rat hippocampus', Neuroscience Letters, vol. 119, no. 2, pp. 272-276. https://doi.org/10.1016/0304-3940(90)90851-Y
Harrison, Neil L. ; Lovinger, David M. ; Lambert, Nevin A ; Teyler, Timothy J. ; Prager, Rolf ; Ong, Jennifer ; Kerr, David I.B. / The actions of 2-hydroxy-saclofen at presynaptic GABAB receptors in the rat hippocampus. In: Neuroscience Letters. 1990 ; Vol. 119, No. 2. pp. 272-276.
@article{f0fe0e8e11f247329658d57f89f53319,
title = "The actions of 2-hydroxy-saclofen at presynaptic GABAB receptors in the rat hippocampus",
abstract = "The actions of 2-hydroxy-saclofen (2-OH-S), a recently develoepd analog of baclofen, were studied at presynaptic GABAB receptors in the rat hippocampal slice. Baclofen (0.5-20 μM) reduces the amplitude of excitatory postsynaptic potentials (EPSPs) recorded from hippocampal CA1 pyramidal neurons. In the presence of 200-500 μM 2-OH-S, the synaptic depressant action of baclofen is significantly reduced. These data show that 2-OH-S is an effective antagonist at presynaptic GABAB receptors on excitatory terminals in the hippocampus.",
keywords = "2-Hydroxysaclofen, GABA receptor, Hippocampus, Rat",
author = "Harrison, {Neil L.} and Lovinger, {David M.} and Lambert, {Nevin A} and Teyler, {Timothy J.} and Rolf Prager and Jennifer Ong and Kerr, {David I.B.}",
year = "1990",
month = "11",
day = "13",
doi = "10.1016/0304-3940(90)90851-Y",
language = "English (US)",
volume = "119",
pages = "272--276",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - The actions of 2-hydroxy-saclofen at presynaptic GABAB receptors in the rat hippocampus

AU - Harrison, Neil L.

AU - Lovinger, David M.

AU - Lambert, Nevin A

AU - Teyler, Timothy J.

AU - Prager, Rolf

AU - Ong, Jennifer

AU - Kerr, David I.B.

PY - 1990/11/13

Y1 - 1990/11/13

N2 - The actions of 2-hydroxy-saclofen (2-OH-S), a recently develoepd analog of baclofen, were studied at presynaptic GABAB receptors in the rat hippocampal slice. Baclofen (0.5-20 μM) reduces the amplitude of excitatory postsynaptic potentials (EPSPs) recorded from hippocampal CA1 pyramidal neurons. In the presence of 200-500 μM 2-OH-S, the synaptic depressant action of baclofen is significantly reduced. These data show that 2-OH-S is an effective antagonist at presynaptic GABAB receptors on excitatory terminals in the hippocampus.

AB - The actions of 2-hydroxy-saclofen (2-OH-S), a recently develoepd analog of baclofen, were studied at presynaptic GABAB receptors in the rat hippocampal slice. Baclofen (0.5-20 μM) reduces the amplitude of excitatory postsynaptic potentials (EPSPs) recorded from hippocampal CA1 pyramidal neurons. In the presence of 200-500 μM 2-OH-S, the synaptic depressant action of baclofen is significantly reduced. These data show that 2-OH-S is an effective antagonist at presynaptic GABAB receptors on excitatory terminals in the hippocampus.

KW - 2-Hydroxysaclofen

KW - GABA receptor

KW - Hippocampus

KW - Rat

UR - http://www.scopus.com/inward/record.url?scp=0025012048&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025012048&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(90)90851-Y

DO - 10.1016/0304-3940(90)90851-Y

M3 - Article

VL - 119

SP - 272

EP - 276

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -