The actions of 2-hydroxy-saclofen at presynaptic GABAB receptors in the rat hippocampus

Neil L. Harrison, David M. Lovinger, Nevin A Lambert, Timothy J. Teyler, Rolf Prager, Jennifer Ong, David I.B. Kerr

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41 Scopus citations

Abstract

The actions of 2-hydroxy-saclofen (2-OH-S), a recently develoepd analog of baclofen, were studied at presynaptic GABAB receptors in the rat hippocampal slice. Baclofen (0.5-20 μM) reduces the amplitude of excitatory postsynaptic potentials (EPSPs) recorded from hippocampal CA1 pyramidal neurons. In the presence of 200-500 μM 2-OH-S, the synaptic depressant action of baclofen is significantly reduced. These data show that 2-OH-S is an effective antagonist at presynaptic GABAB receptors on excitatory terminals in the hippocampus.

Original languageEnglish (US)
Pages (from-to)272-276
Number of pages5
JournalNeuroscience Letters
Volume119
Issue number2
DOIs
StatePublished - Nov 13 1990
Externally publishedYes

Keywords

  • 2-Hydroxysaclofen
  • GABA receptor
  • Hippocampus
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

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    Harrison, N. L., Lovinger, D. M., Lambert, N. A., Teyler, T. J., Prager, R., Ong, J., & Kerr, D. I. B. (1990). The actions of 2-hydroxy-saclofen at presynaptic GABAB receptors in the rat hippocampus. Neuroscience Letters, 119(2), 272-276. https://doi.org/10.1016/0304-3940(90)90851-Y