The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani

Chad E. Stephens, Reto Brun, Manar M. Salem, Karl A. Werbovetz, Farial Tanious, W. David Wilson, David W. Boykin

Research output: Contribution to journalArticle

67 Scopus citations


The in vitro activity of 20 dicationic molecules containing either diguanidino or reversed amidine cationic groups were evaluated versus Trypanosoma cruzi and Leishmania donovani. The most active compounds were in the reversed amidine series and six exhibited IC50 values of less than 1 μmol versus T. cruzi and five gave similar values versus L. donovani.

Original languageEnglish (US)
Pages (from-to)2065-2069
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number12
StatePublished - Jun 16 2003
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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