The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani

Chad E. Stephens, Reto Brun, Manar M. Salem, Karl A. Werbovetz, Farial Tanious, W. David Wilson, David W. Boykin

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The in vitro activity of 20 dicationic molecules containing either diguanidino or reversed amidine cationic groups were evaluated versus Trypanosoma cruzi and Leishmania donovani. The most active compounds were in the reversed amidine series and six exhibited IC50 values of less than 1 μmol versus T. cruzi and five gave similar values versus L. donovani.

Original languageEnglish (US)
Pages (from-to)2065-2069
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number12
DOIs
StatePublished - Jun 16 2003

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Amidines
Leishmania donovani
Trypanosoma cruzi
Inhibitory Concentration 50
Molecules
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani. / Stephens, Chad E.; Brun, Reto; Salem, Manar M.; Werbovetz, Karl A.; Tanious, Farial; Wilson, W. David; Boykin, David W.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 13, No. 12, 16.06.2003, p. 2065-2069.

Research output: Contribution to journalArticle

Stephens, Chad E. ; Brun, Reto ; Salem, Manar M. ; Werbovetz, Karl A. ; Tanious, Farial ; Wilson, W. David ; Boykin, David W. / The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani. In: Bioorganic and Medicinal Chemistry Letters. 2003 ; Vol. 13, No. 12. pp. 2065-2069.
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