TY - JOUR
T1 - The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome
T2 - the complete task force report
AU - Azziz, Ricardo
AU - Carmina, Enrico
AU - Dewailly, Didier
AU - Diamanti-Kandarakis, Evanthia
AU - Escobar-Morreale, Héctor F.
AU - Futterweit, Walter
AU - Janssen, Onno E.
AU - Legro, Richard S.
AU - Norman, Robert J.
AU - Taylor, Ann E.
AU - Witchel, Selma F.
N1 - Funding Information:
Previously, two definitions of PCOS were in widespread use ( Table 1 ). The first arose from the proceedings of an expert conference sponsored in part by the National Institute of Child Health and Human Disease (NICHD) of the NIH on April 16–18, 1990. During the meeting all participants were surveyed regarding their perception of what features formed part of PCOS, and Drs. Zawadzki and Dunaif summarized these findings in the meeting proceedings (13) . They concluded that the major criteria for PCOS “should include (in order of importance): i) hyperandrogenism and/or hyperandrogenemia, ii) menstrual dysfunction, (and the) iii) exclusion of other known disorders.” This survey identified PCOS as an androgen excess disorder of exclusion, with an ovarian etiology and/or consequences.
PY - 2009/2
Y1 - 2009/2
N2 - Objective: To review all available data and recommend a definition for polycystic ovary syndrome (PCOS) based on published peer-reviewed data, whether already in use or not, to guide clinical diagnosis and future research. Design: Literature review and expert consensus. Setting: Professional society. Patients: None. Intervention(s): None. Main Outcome Measure(s): A systematic review of the published peer-reviewed medical literature, by querying MEDLINE databases, to identify studies evaluating the epidemiology or phenotypic aspects of PCOS. Result(s): The Task Force drafted the initial report, following a consensus process via electronic communication, which was then reviewed and critiqued by the Androgen Excess and PCOS (AE-PCOS) Society AE-PCOS Board of Directors. No section was finalized until all members were satisfied with the contents, and minority opinions noted. Statements were not included that were not supported by peer-reviewed evidence. Conclusion(s): Based on the available data, it is the view of the AE-PCOS Society Task Force that PCOS should be defined by the presence of hyperandrogenism (clinical and/or biochemical), ovarian dysfunction (oligo-anovulation and/or polycystic ovaries), and the exclusion of related disorders. However, a minority considered the possibility that there may be forms of PCOS without overt evidence of hyperandrogenism, but recognized that more data are required before validating this supposition. Finally, the Task Force recognized and fully expects that the definition of this syndrome will evolve over time to incorporate new research findings.
AB - Objective: To review all available data and recommend a definition for polycystic ovary syndrome (PCOS) based on published peer-reviewed data, whether already in use or not, to guide clinical diagnosis and future research. Design: Literature review and expert consensus. Setting: Professional society. Patients: None. Intervention(s): None. Main Outcome Measure(s): A systematic review of the published peer-reviewed medical literature, by querying MEDLINE databases, to identify studies evaluating the epidemiology or phenotypic aspects of PCOS. Result(s): The Task Force drafted the initial report, following a consensus process via electronic communication, which was then reviewed and critiqued by the Androgen Excess and PCOS (AE-PCOS) Society AE-PCOS Board of Directors. No section was finalized until all members were satisfied with the contents, and minority opinions noted. Statements were not included that were not supported by peer-reviewed evidence. Conclusion(s): Based on the available data, it is the view of the AE-PCOS Society Task Force that PCOS should be defined by the presence of hyperandrogenism (clinical and/or biochemical), ovarian dysfunction (oligo-anovulation and/or polycystic ovaries), and the exclusion of related disorders. However, a minority considered the possibility that there may be forms of PCOS without overt evidence of hyperandrogenism, but recognized that more data are required before validating this supposition. Finally, the Task Force recognized and fully expects that the definition of this syndrome will evolve over time to incorporate new research findings.
KW - Polycystic ovary syndrome
KW - criteria
KW - hirsutism
KW - menstrual dysfunction
KW - phenotype
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U2 - 10.1016/j.fertnstert.2008.06.035
DO - 10.1016/j.fertnstert.2008.06.035
M3 - Article
C2 - 18950759
AN - SCOPUS:59349098805
SN - 0015-0282
VL - 91
SP - 456
EP - 488
JO - Fertility and sterility
JF - Fertility and sterility
IS - 2
ER -