TY - JOUR
T1 - The anesthetic efficacy of 4 percent articaine 1:200,000 epinephrine
T2 - Two controlled clinical trials
AU - Moore, Paul A.
AU - Boynes, Sean C.
AU - Hersh, Elliot V.
AU - DeRossi, Scott S.
AU - Sollecito, Thomas P.
AU - Goodson, J. Max
AU - Leonel, Juliana S.
AU - Floros, Constantinos
AU - Peterson, Carrie
AU - Hutcheson, Matthew
PY - 2006/11
Y1 - 2006/11
N2 - Objective. The authors conducted two double-blinded, randomized, multicenter clinical trials to determine the efficacy and clinical anesthetic characteristics of 4 percent articaine hydrochloride (HCl) with 1:200,000 epinephrine (A200) as compared with those of 4 percent articaine HCl with 1:100,060 epinephrine (A100) and 4 percent articaine HCl without epinephrine (Aw/o). Methods. During separate testing sessions, members of the authors' research team used three articaine study formulations to induce either inferior alveolar nerve block anesthesia (Trial 1) or maxillary infiltration anesthesia (Trial 2). In each trial, subjects received, in a randomized sequence, each of the three formulations to determine efficacy (success rate) and anesthetic characteristics (onset time and duration). The authors evaluated pulpal anesthesia via subjects' response to electric pulp testing (EPT). Results. A total of 126 subjects were enrolled in the two studies (63 subjects in each trial). In both mandibular and maxillary trials, the success rates for inducing profound anesthesia (EPT score ≥ 80), the mean onset times and the mean durations of anesthesia were similar for both epinephrine-containing formulations (A200 and A100). In subjects who received the formulation containing no epinephrine (Aw/o), the success rate for profound anesthesia was significantly less. Conclusion. These studies demonstrated that the inclusion of epinephrine in 4 percent articaine anesthetic formulations is essential for achieving profound anesthesia. The authors found that the A200 formulation provided a level of pulpal anesthesia comparable with that of the A100 formulation.
AB - Objective. The authors conducted two double-blinded, randomized, multicenter clinical trials to determine the efficacy and clinical anesthetic characteristics of 4 percent articaine hydrochloride (HCl) with 1:200,000 epinephrine (A200) as compared with those of 4 percent articaine HCl with 1:100,060 epinephrine (A100) and 4 percent articaine HCl without epinephrine (Aw/o). Methods. During separate testing sessions, members of the authors' research team used three articaine study formulations to induce either inferior alveolar nerve block anesthesia (Trial 1) or maxillary infiltration anesthesia (Trial 2). In each trial, subjects received, in a randomized sequence, each of the three formulations to determine efficacy (success rate) and anesthetic characteristics (onset time and duration). The authors evaluated pulpal anesthesia via subjects' response to electric pulp testing (EPT). Results. A total of 126 subjects were enrolled in the two studies (63 subjects in each trial). In both mandibular and maxillary trials, the success rates for inducing profound anesthesia (EPT score ≥ 80), the mean onset times and the mean durations of anesthesia were similar for both epinephrine-containing formulations (A200 and A100). In subjects who received the formulation containing no epinephrine (Aw/o), the success rate for profound anesthesia was significantly less. Conclusion. These studies demonstrated that the inclusion of epinephrine in 4 percent articaine anesthetic formulations is essential for achieving profound anesthesia. The authors found that the A200 formulation provided a level of pulpal anesthesia comparable with that of the A100 formulation.
KW - Articaine
KW - Clinical trial
KW - Dentistry
KW - Epinephrine
KW - Local anesthesia
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U2 - 10.14219/jada.archive.2006.0093
DO - 10.14219/jada.archive.2006.0093
M3 - Article
C2 - 17082284
AN - SCOPUS:33845283870
SN - 0002-8177
VL - 137
SP - 1572
EP - 1581
JO - Journal of the American Dental Association
JF - Journal of the American Dental Association
IS - 11
ER -