The association of fatty acid levels and gleason grade among men undergoing radical prostatectomy

Zhiguo Zhao, Lael Reinstatler, Zachary W A Klaassen, Yi Xu, Xiaoyu Yang, Rabii Hussein Madi, Martha Kennedy Terris, Steven Y. Qian, Uddhav Kelavkar, Kelvin A. Moses

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background Epidemiological data suggest that omega-6 (ω-6) fatty acids (FAs) may be associated with cancer incidence and/or cancer mortality, whereas ω-3 FAs are potentially protective. We examined the association of the ratio of ω-6 to ω-3 FA (ω-6:ω-3) and individual FA components with pathological results among men with prostate cancer (PCa) undergoing radical prostatectomy. Methods Sixty-nine men were included in the study. Components of ω-6 (linoleic acid (LA), arachidonic acid (AA), and dihomo-γ-linolenic acid (DGLA)) and ω-3 (docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)) were analyzed by liquid chromatography/mass selective detector separation. Logistic regression analysis was performed to determine association of FA with pathological high grade (Gleason >4+3) disease. Results The were 35 men with low grade disease (Gleason <3+4) and 34 men with high grade disease. Men with low grade disease were significantly younger (58y vs 61y, p = 0.012) and had lower D'Amico clinical classification (p = 0.001) compared to men with high grade disease. There was no significant association of 00-6:00-3 with high grade disease (OR 0.93, p = 0.78), however overall ω-6, ω-3, and individual components of ω-6 and ω-3 FAs except EPA were significantly associated with high grade disease (ω-6: OR 3.37, 95% CI: 1.27,8.98; LA: OR 3.33, 95% CI:1.24,8.94; AA: OR 2.93, 95% CI:1.24,6.94; DGLA: OR 3.21, 95% CI:1.28,8.04; ω-3: OR 3.47, 95% CI:1.22,9.83; DHA: OR 3.13, 95% CI:1.26,7.74). ω-6 and ω-3 FA components were highly correlated (Spearman ρ = 0.77). Conclusion Higher levels of individual components of ω-6 and ω-3FAs may be associated with highergrade PCa. Impact Studies into the causative factors/pathways regarding FAs and prostate carcinogenesis may prove a potential association with PCa aggressiveness.

Original languageEnglish (US)
Article numbere0166594
JournalPloS one
Volume11
Issue number11
DOIs
StatePublished - Nov 1 2016

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Prostatectomy
Fatty Acids
Association reactions
fatty acids
prostatic neoplasms
Eicosapentaenoic Acid
Docosahexaenoic Acids
eicosapentaenoic acid
docosahexaenoic acid
arachidonic acid
Arachidonic Acid
Prostatic Neoplasms
neoplasms
alpha-Linolenic Acid
Liquid chromatography
Linoleic Acid
linolenic acid
Regression analysis
Liquid Chromatography
carcinogenesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

The association of fatty acid levels and gleason grade among men undergoing radical prostatectomy. / Zhao, Zhiguo; Reinstatler, Lael; Klaassen, Zachary W A; Xu, Yi; Yang, Xiaoyu; Madi, Rabii Hussein; Terris, Martha Kennedy; Qian, Steven Y.; Kelavkar, Uddhav; Moses, Kelvin A.

In: PloS one, Vol. 11, No. 11, e0166594, 01.11.2016.

Research output: Contribution to journalArticle

Zhao, Zhiguo ; Reinstatler, Lael ; Klaassen, Zachary W A ; Xu, Yi ; Yang, Xiaoyu ; Madi, Rabii Hussein ; Terris, Martha Kennedy ; Qian, Steven Y. ; Kelavkar, Uddhav ; Moses, Kelvin A. / The association of fatty acid levels and gleason grade among men undergoing radical prostatectomy. In: PloS one. 2016 ; Vol. 11, No. 11.
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abstract = "Background Epidemiological data suggest that omega-6 (ω-6) fatty acids (FAs) may be associated with cancer incidence and/or cancer mortality, whereas ω-3 FAs are potentially protective. We examined the association of the ratio of ω-6 to ω-3 FA (ω-6:ω-3) and individual FA components with pathological results among men with prostate cancer (PCa) undergoing radical prostatectomy. Methods Sixty-nine men were included in the study. Components of ω-6 (linoleic acid (LA), arachidonic acid (AA), and dihomo-γ-linolenic acid (DGLA)) and ω-3 (docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)) were analyzed by liquid chromatography/mass selective detector separation. Logistic regression analysis was performed to determine association of FA with pathological high grade (Gleason >4+3) disease. Results The were 35 men with low grade disease (Gleason <3+4) and 34 men with high grade disease. Men with low grade disease were significantly younger (58y vs 61y, p = 0.012) and had lower D'Amico clinical classification (p = 0.001) compared to men with high grade disease. There was no significant association of 00-6:00-3 with high grade disease (OR 0.93, p = 0.78), however overall ω-6, ω-3, and individual components of ω-6 and ω-3 FAs except EPA were significantly associated with high grade disease (ω-6: OR 3.37, 95{\%} CI: 1.27,8.98; LA: OR 3.33, 95{\%} CI:1.24,8.94; AA: OR 2.93, 95{\%} CI:1.24,6.94; DGLA: OR 3.21, 95{\%} CI:1.28,8.04; ω-3: OR 3.47, 95{\%} CI:1.22,9.83; DHA: OR 3.13, 95{\%} CI:1.26,7.74). ω-6 and ω-3 FA components were highly correlated (Spearman ρ = 0.77). Conclusion Higher levels of individual components of ω-6 and ω-3FAs may be associated with highergrade PCa. Impact Studies into the causative factors/pathways regarding FAs and prostate carcinogenesis may prove a potential association with PCa aggressiveness.",
author = "Zhiguo Zhao and Lael Reinstatler and Klaassen, {Zachary W A} and Yi Xu and Xiaoyu Yang and Madi, {Rabii Hussein} and Terris, {Martha Kennedy} and Qian, {Steven Y.} and Uddhav Kelavkar and Moses, {Kelvin A.}",
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T1 - The association of fatty acid levels and gleason grade among men undergoing radical prostatectomy

AU - Zhao, Zhiguo

AU - Reinstatler, Lael

AU - Klaassen, Zachary W A

AU - Xu, Yi

AU - Yang, Xiaoyu

AU - Madi, Rabii Hussein

AU - Terris, Martha Kennedy

AU - Qian, Steven Y.

AU - Kelavkar, Uddhav

AU - Moses, Kelvin A.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Background Epidemiological data suggest that omega-6 (ω-6) fatty acids (FAs) may be associated with cancer incidence and/or cancer mortality, whereas ω-3 FAs are potentially protective. We examined the association of the ratio of ω-6 to ω-3 FA (ω-6:ω-3) and individual FA components with pathological results among men with prostate cancer (PCa) undergoing radical prostatectomy. Methods Sixty-nine men were included in the study. Components of ω-6 (linoleic acid (LA), arachidonic acid (AA), and dihomo-γ-linolenic acid (DGLA)) and ω-3 (docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)) were analyzed by liquid chromatography/mass selective detector separation. Logistic regression analysis was performed to determine association of FA with pathological high grade (Gleason >4+3) disease. Results The were 35 men with low grade disease (Gleason <3+4) and 34 men with high grade disease. Men with low grade disease were significantly younger (58y vs 61y, p = 0.012) and had lower D'Amico clinical classification (p = 0.001) compared to men with high grade disease. There was no significant association of 00-6:00-3 with high grade disease (OR 0.93, p = 0.78), however overall ω-6, ω-3, and individual components of ω-6 and ω-3 FAs except EPA were significantly associated with high grade disease (ω-6: OR 3.37, 95% CI: 1.27,8.98; LA: OR 3.33, 95% CI:1.24,8.94; AA: OR 2.93, 95% CI:1.24,6.94; DGLA: OR 3.21, 95% CI:1.28,8.04; ω-3: OR 3.47, 95% CI:1.22,9.83; DHA: OR 3.13, 95% CI:1.26,7.74). ω-6 and ω-3 FA components were highly correlated (Spearman ρ = 0.77). Conclusion Higher levels of individual components of ω-6 and ω-3FAs may be associated with highergrade PCa. Impact Studies into the causative factors/pathways regarding FAs and prostate carcinogenesis may prove a potential association with PCa aggressiveness.

AB - Background Epidemiological data suggest that omega-6 (ω-6) fatty acids (FAs) may be associated with cancer incidence and/or cancer mortality, whereas ω-3 FAs are potentially protective. We examined the association of the ratio of ω-6 to ω-3 FA (ω-6:ω-3) and individual FA components with pathological results among men with prostate cancer (PCa) undergoing radical prostatectomy. Methods Sixty-nine men were included in the study. Components of ω-6 (linoleic acid (LA), arachidonic acid (AA), and dihomo-γ-linolenic acid (DGLA)) and ω-3 (docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)) were analyzed by liquid chromatography/mass selective detector separation. Logistic regression analysis was performed to determine association of FA with pathological high grade (Gleason >4+3) disease. Results The were 35 men with low grade disease (Gleason <3+4) and 34 men with high grade disease. Men with low grade disease were significantly younger (58y vs 61y, p = 0.012) and had lower D'Amico clinical classification (p = 0.001) compared to men with high grade disease. There was no significant association of 00-6:00-3 with high grade disease (OR 0.93, p = 0.78), however overall ω-6, ω-3, and individual components of ω-6 and ω-3 FAs except EPA were significantly associated with high grade disease (ω-6: OR 3.37, 95% CI: 1.27,8.98; LA: OR 3.33, 95% CI:1.24,8.94; AA: OR 2.93, 95% CI:1.24,6.94; DGLA: OR 3.21, 95% CI:1.28,8.04; ω-3: OR 3.47, 95% CI:1.22,9.83; DHA: OR 3.13, 95% CI:1.26,7.74). ω-6 and ω-3 FA components were highly correlated (Spearman ρ = 0.77). Conclusion Higher levels of individual components of ω-6 and ω-3FAs may be associated with highergrade PCa. Impact Studies into the causative factors/pathways regarding FAs and prostate carcinogenesis may prove a potential association with PCa aggressiveness.

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