The ATP-dependent chromatin remodeling enzyme Fun30 represses transcription by sliding promoter-proximal nucleosomes

Boseon Byeon, Wei Wang, Artem Barski, Ryan T. Ranallo, Kan Bao, Dustin E. Schones, Keji Zhao, Carl Wu, Wei-Hua Wu

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    Background: The conserved ATP-dependent chromatin remodeling enzyme Fun30 regulates heterochromatin silencing and DNA repair. Results: Gene expression is up-regulated, and nucleosome positioning is altered in fun30Δ cells, and purified Fun30 slides nucleosome in vitro. Conclusion: Fun30 represses gene expression by sliding promoter-proximal nucleosomes. Significance: The function of Fun30 is expanded to regulation of transcription and chromatin remodeling by nucleosome sliding.

    Original languageEnglish (US)
    Pages (from-to)23182-23193
    Number of pages12
    JournalJournal of Biological Chemistry
    Volume288
    Issue number32
    DOIs
    StatePublished - Aug 9 2013

    Fingerprint

    Chromatin Assembly and Disassembly
    Nucleosomes
    Transcription
    Chromatin
    Adenosine Triphosphate
    Enzymes
    Gene expression
    Gene Expression
    Heterochromatin
    DNA Repair
    Repair
    DNA

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Cell Biology

    Cite this

    The ATP-dependent chromatin remodeling enzyme Fun30 represses transcription by sliding promoter-proximal nucleosomes. / Byeon, Boseon; Wang, Wei; Barski, Artem; Ranallo, Ryan T.; Bao, Kan; Schones, Dustin E.; Zhao, Keji; Wu, Carl; Wu, Wei-Hua.

    In: Journal of Biological Chemistry, Vol. 288, No. 32, 09.08.2013, p. 23182-23193.

    Research output: Contribution to journalArticle

    Byeon, B, Wang, W, Barski, A, Ranallo, RT, Bao, K, Schones, DE, Zhao, K, Wu, C & Wu, W-H 2013, 'The ATP-dependent chromatin remodeling enzyme Fun30 represses transcription by sliding promoter-proximal nucleosomes', Journal of Biological Chemistry, vol. 288, no. 32, pp. 23182-23193. https://doi.org/10.1074/jbc.M113.471979
    Byeon, Boseon ; Wang, Wei ; Barski, Artem ; Ranallo, Ryan T. ; Bao, Kan ; Schones, Dustin E. ; Zhao, Keji ; Wu, Carl ; Wu, Wei-Hua. / The ATP-dependent chromatin remodeling enzyme Fun30 represses transcription by sliding promoter-proximal nucleosomes. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 32. pp. 23182-23193.
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    AU - Bao, Kan

    AU - Schones, Dustin E.

    AU - Zhao, Keji

    AU - Wu, Carl

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