The ATP-dependent chromatin remodeling enzyme Fun30 represses transcription by sliding promoter-proximal nucleosomes

Boseon Byeon, Wei Wang, Artem Barski, Ryan T. Ranallo, Kan Bao, Dustin E. Schones, Keji Zhao, Carl Wu, Wei Hua Wu

    Research output: Contribution to journalArticlepeer-review

    22 Scopus citations

    Abstract

    Background: The conserved ATP-dependent chromatin remodeling enzyme Fun30 regulates heterochromatin silencing and DNA repair. Results: Gene expression is up-regulated, and nucleosome positioning is altered in fun30Δ cells, and purified Fun30 slides nucleosome in vitro. Conclusion: Fun30 represses gene expression by sliding promoter-proximal nucleosomes. Significance: The function of Fun30 is expanded to regulation of transcription and chromatin remodeling by nucleosome sliding.

    Original languageEnglish (US)
    Pages (from-to)23182-23193
    Number of pages12
    JournalJournal of Biological Chemistry
    Volume288
    Issue number32
    DOIs
    StatePublished - Aug 9 2013

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Cell Biology

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