Abstract
Background: The TGR5 bile acid receptor controls energy balance, inflammation, and digestion, but TGR5 signaling is poorly understood. Results: TGR5 does not interact with β-arrestins, internalize, or desensitize, but signals from plasma membrane rafts. Conclusion: TGR5 transmits sustained signals close to the cell surface. Significance: Understanding TGR5 signaling will facilitate design of TGR5 agonists for metabolic, inflammatory, and digestive disorders.
Original language | English (US) |
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Pages (from-to) | 22942-22960 |
Number of pages | 19 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 32 |
DOIs | |
State | Published - Aug 9 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology